Axial and peripheral spondyloarthritis: does psoriasis influence the clinical expression and disease burden? Data from REGISPONSER registry

Abstract Objective To evaluate whether the presence of psoriasis influences the clinical expression, disease activity and disease burden in both axial and peripheral phenotypes of spondyloarthritis (SpA). Methods Patients from the Spanish REGISPONSER registry classified as having SpA according to th...

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Published in:Rheumatology (Oxford, England) England), 2021-03, Vol.60 (3), p.1125-1136
Main Authors: López-Medina, Clementina, Ortega-Castro, Rafaela, Castro-Villegas, M Carmen, Font-Ugalde, Pilar, Puche-Larrubia, M Ángeles, Gómez-García, Ignacio, Arias-de la Rosa, Iván, Barbarroja, Nuria, Schiotis, Ruxandra, Collantes-Estévez, Eduardo
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creator López-Medina, Clementina
Ortega-Castro, Rafaela
Castro-Villegas, M Carmen
Font-Ugalde, Pilar
Puche-Larrubia, M Ángeles
Gómez-García, Ignacio
Arias-de la Rosa, Iván
Barbarroja, Nuria
Schiotis, Ruxandra
Collantes-Estévez, Eduardo
description Abstract Objective To evaluate whether the presence of psoriasis influences the clinical expression, disease activity and disease burden in both axial and peripheral phenotypes of spondyloarthritis (SpA). Methods Patients from the Spanish REGISPONSER registry classified as having SpA according to the ESSG criteria were included. Patients were classified as psoriatic or non-psoriatic depending on the presence of cutaneous or nail psoriasis; thereafter, they were classified as having either axial [presence of radiographic sacroiliitis OR inflammatory back pain (IBP)] or peripheral phenotype (absence of radiographic sacroiliitis AND absence of IBP AND presence of peripheral involvement). Pair-wise univariate and multivariate analyses among the four groups (psoriatic/non-psoriatic axial phenotypes and psoriatic/non-psoriatic peripheral phenotypes) were performed with adjustment for treatment intake. Results A total of 2296 patients were included in the analysis. Among patients with axial phenotype, psoriasis was independently associated (P 
doi_str_mv 10.1093/rheumatology/keaa398
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Data from REGISPONSER registry</title><source>Oxford Journals Online</source><source>Alma/SFX Local Collection</source><creator>López-Medina, Clementina ; Ortega-Castro, Rafaela ; Castro-Villegas, M Carmen ; Font-Ugalde, Pilar ; Puche-Larrubia, M Ángeles ; Gómez-García, Ignacio ; Arias-de la Rosa, Iván ; Barbarroja, Nuria ; Schiotis, Ruxandra ; Collantes-Estévez, Eduardo</creator><creatorcontrib>López-Medina, Clementina ; Ortega-Castro, Rafaela ; Castro-Villegas, M Carmen ; Font-Ugalde, Pilar ; Puche-Larrubia, M Ángeles ; Gómez-García, Ignacio ; Arias-de la Rosa, Iván ; Barbarroja, Nuria ; Schiotis, Ruxandra ; Collantes-Estévez, Eduardo</creatorcontrib><description>Abstract Objective To evaluate whether the presence of psoriasis influences the clinical expression, disease activity and disease burden in both axial and peripheral phenotypes of spondyloarthritis (SpA). Methods Patients from the Spanish REGISPONSER registry classified as having SpA according to the ESSG criteria were included. Patients were classified as psoriatic or non-psoriatic depending on the presence of cutaneous or nail psoriasis; thereafter, they were classified as having either axial [presence of radiographic sacroiliitis OR inflammatory back pain (IBP)] or peripheral phenotype (absence of radiographic sacroiliitis AND absence of IBP AND presence of peripheral involvement). Pair-wise univariate and multivariate analyses among the four groups (psoriatic/non-psoriatic axial phenotypes and psoriatic/non-psoriatic peripheral phenotypes) were performed with adjustment for treatment intake. Results A total of 2296 patients were included in the analysis. Among patients with axial phenotype, psoriasis was independently associated (P &lt; 0.05) with HLA-B27+ [odds ratio (OR) 0.27], uveitis (OR 0.46), synovitis (ever) (OR 2.59), dactylitis (OR 2.78) and the use of conventional synthetic DMARDs (csDMARDs) (OR 1.47) in comparison with non-psoriatic patients. Among patients with peripheral phenotype and adjusting for csDMARD intake, psoriasis was independently associated with higher age at disease onset (OR 1.05), HLA-B27+ (OR 0.14) and heel enthesitis (OR 0.22). Higher scores for patient-reported outcomes and greater use of treatment at the time of the study visit were observed in psoriatic patients with either axial or peripheral phenotype. Conclusion These findings suggest that, among all patients with SpA, psoriasis is associated with differences in clinical expression of SpA, a greater disease burden and increased use of drugs.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keaa398</identifier><identifier>PMID: 32856083</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Rheumatology (Oxford, England), 2021-03, Vol.60 (3), p.1125-1136</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-cbc8738fa4e41771287c86fd6625723f01ca251e339f428d02f258f8394e01003</citedby><cites>FETCH-LOGICAL-c347t-cbc8738fa4e41771287c86fd6625723f01ca251e339f428d02f258f8394e01003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32856083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López-Medina, Clementina</creatorcontrib><creatorcontrib>Ortega-Castro, Rafaela</creatorcontrib><creatorcontrib>Castro-Villegas, M Carmen</creatorcontrib><creatorcontrib>Font-Ugalde, Pilar</creatorcontrib><creatorcontrib>Puche-Larrubia, M Ángeles</creatorcontrib><creatorcontrib>Gómez-García, Ignacio</creatorcontrib><creatorcontrib>Arias-de la Rosa, Iván</creatorcontrib><creatorcontrib>Barbarroja, Nuria</creatorcontrib><creatorcontrib>Schiotis, Ruxandra</creatorcontrib><creatorcontrib>Collantes-Estévez, Eduardo</creatorcontrib><title>Axial and peripheral spondyloarthritis: does psoriasis influence the clinical expression and disease burden? Data from REGISPONSER registry</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Abstract Objective To evaluate whether the presence of psoriasis influences the clinical expression, disease activity and disease burden in both axial and peripheral phenotypes of spondyloarthritis (SpA). Methods Patients from the Spanish REGISPONSER registry classified as having SpA according to the ESSG criteria were included. Patients were classified as psoriatic or non-psoriatic depending on the presence of cutaneous or nail psoriasis; thereafter, they were classified as having either axial [presence of radiographic sacroiliitis OR inflammatory back pain (IBP)] or peripheral phenotype (absence of radiographic sacroiliitis AND absence of IBP AND presence of peripheral involvement). Pair-wise univariate and multivariate analyses among the four groups (psoriatic/non-psoriatic axial phenotypes and psoriatic/non-psoriatic peripheral phenotypes) were performed with adjustment for treatment intake. Results A total of 2296 patients were included in the analysis. Among patients with axial phenotype, psoriasis was independently associated (P &lt; 0.05) with HLA-B27+ [odds ratio (OR) 0.27], uveitis (OR 0.46), synovitis (ever) (OR 2.59), dactylitis (OR 2.78) and the use of conventional synthetic DMARDs (csDMARDs) (OR 1.47) in comparison with non-psoriatic patients. Among patients with peripheral phenotype and adjusting for csDMARD intake, psoriasis was independently associated with higher age at disease onset (OR 1.05), HLA-B27+ (OR 0.14) and heel enthesitis (OR 0.22). Higher scores for patient-reported outcomes and greater use of treatment at the time of the study visit were observed in psoriatic patients with either axial or peripheral phenotype. 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Data from REGISPONSER registry</title><author>López-Medina, Clementina ; Ortega-Castro, Rafaela ; Castro-Villegas, M Carmen ; Font-Ugalde, Pilar ; Puche-Larrubia, M Ángeles ; Gómez-García, Ignacio ; Arias-de la Rosa, Iván ; Barbarroja, Nuria ; Schiotis, Ruxandra ; Collantes-Estévez, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-cbc8738fa4e41771287c86fd6625723f01ca251e339f428d02f258f8394e01003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Medina, Clementina</creatorcontrib><creatorcontrib>Ortega-Castro, Rafaela</creatorcontrib><creatorcontrib>Castro-Villegas, M Carmen</creatorcontrib><creatorcontrib>Font-Ugalde, Pilar</creatorcontrib><creatorcontrib>Puche-Larrubia, M Ángeles</creatorcontrib><creatorcontrib>Gómez-García, Ignacio</creatorcontrib><creatorcontrib>Arias-de la Rosa, Iván</creatorcontrib><creatorcontrib>Barbarroja, Nuria</creatorcontrib><creatorcontrib>Schiotis, Ruxandra</creatorcontrib><creatorcontrib>Collantes-Estévez, Eduardo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-Medina, Clementina</au><au>Ortega-Castro, Rafaela</au><au>Castro-Villegas, M Carmen</au><au>Font-Ugalde, Pilar</au><au>Puche-Larrubia, M Ángeles</au><au>Gómez-García, Ignacio</au><au>Arias-de la Rosa, Iván</au><au>Barbarroja, Nuria</au><au>Schiotis, Ruxandra</au><au>Collantes-Estévez, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Axial and peripheral spondyloarthritis: does psoriasis influence the clinical expression and disease burden? Data from REGISPONSER registry</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2021-03-02</date><risdate>2021</risdate><volume>60</volume><issue>3</issue><spage>1125</spage><epage>1136</epage><pages>1125-1136</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>Abstract Objective To evaluate whether the presence of psoriasis influences the clinical expression, disease activity and disease burden in both axial and peripheral phenotypes of spondyloarthritis (SpA). Methods Patients from the Spanish REGISPONSER registry classified as having SpA according to the ESSG criteria were included. Patients were classified as psoriatic or non-psoriatic depending on the presence of cutaneous or nail psoriasis; thereafter, they were classified as having either axial [presence of radiographic sacroiliitis OR inflammatory back pain (IBP)] or peripheral phenotype (absence of radiographic sacroiliitis AND absence of IBP AND presence of peripheral involvement). Pair-wise univariate and multivariate analyses among the four groups (psoriatic/non-psoriatic axial phenotypes and psoriatic/non-psoriatic peripheral phenotypes) were performed with adjustment for treatment intake. Results A total of 2296 patients were included in the analysis. Among patients with axial phenotype, psoriasis was independently associated (P &lt; 0.05) with HLA-B27+ [odds ratio (OR) 0.27], uveitis (OR 0.46), synovitis (ever) (OR 2.59), dactylitis (OR 2.78) and the use of conventional synthetic DMARDs (csDMARDs) (OR 1.47) in comparison with non-psoriatic patients. Among patients with peripheral phenotype and adjusting for csDMARD intake, psoriasis was independently associated with higher age at disease onset (OR 1.05), HLA-B27+ (OR 0.14) and heel enthesitis (OR 0.22). Higher scores for patient-reported outcomes and greater use of treatment at the time of the study visit were observed in psoriatic patients with either axial or peripheral phenotype. Conclusion These findings suggest that, among all patients with SpA, psoriasis is associated with differences in clinical expression of SpA, a greater disease burden and increased use of drugs.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32856083</pmid><doi>10.1093/rheumatology/keaa398</doi><tpages>12</tpages></addata></record>
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title Axial and peripheral spondyloarthritis: does psoriasis influence the clinical expression and disease burden? Data from REGISPONSER registry
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