Perioperative Outcomes and 5-year Survival After Open versus Thoracoscopic Sleeve Resection for Lung Cancer

• Published in: Seminars in thoracic and cardiovascular surgery 2021-01, Vol.33 (2), p.522-530
• Main Authors: Mayne, Nicholas R., Darling, Alice J., Raman, Vignesh, Balderson, Scott, Berry, Mark F., Harpole, David H., D'Amico, Thomas A., Yang, Chi-Fu Jeffrey
• Format: Article
• Language: English
• Subjects: Long-term survival; National Cancer Data Base; Non-small-cell lung cancer; Perioperative outcomes; Sleeve lobectomy; VATS
• ISSN: 1043-0679; 1532-9488
• DOI: 10.1053/j.semtcvs.2020.08.013

The objective of this study was to evaluate the impact of a video-assisted thoracoscopic (VATS) approach on outcomes in patients who underwent sleeve lobectomy for non-small-cell lung cancer (NSCLC). Outcomes of patients with cT1-T3, N0-N2, M0 NSCLC who underwent sleeve lobectomy in the National Cancer Data Base (NCDB) from 2010-2015 were assessed using Kaplan–Meier, propensity score-matching, and Cox proportional hazards analyses. An “intent-to-treat” analysis was performed. In the NCDB, 210 sleeve lobectomy patients met inclusion criteria (VATS 44 [21%], thoracotomy 166 [79%]). Nine (20%) of the VATS cases were converted to open. Compared to an open approach, VATS was associated with no significant differences in lymph nodes examined (median 9.5 vs 9.0; p = 0.72), length of stay (median 6 days vs 6 days; p = 0.36), 30-day mortality (4.5% vs 1.8%; p = 0.28), and 90-day mortality (6.8% vs 4.8%; p = 0.70). There were no significant differences in 5-year survival between the VATS and open groups in both the entire cohort (VATS [85%] vs open [79%]; log-rank p = 0.91) and in a propensity score-matched analysis of 86 patients (log-rank p = 0.75). Furthermore, a VATS approach was also not associated with worse survival in multivariable analysis (HR = 0.64; 95% CI [0.23-1.78]; p = 0.39). In this national analysis, a VATS approach for sleeve lobectomy for NSCLC was not associated with worse short-term or long-term outcomes when compared to an open approach. [Display omitted]