Weight Gain Induced by Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnea Is Mediated by Fluid Accumulation: A Randomized Crossover Controlled Trial

Recent studies have shown that the treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) is associated with weight gain over periods ranging from 3 to 6 months (1-4). However, the mechanisms are conflicting and include reduction in basal metabolic rate (KMR) beca...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2021-01, Vol.203 (1), p.134-136
Main Authors: Herculano, Sara, Grad, Gustavo F, Drager, Luciano F, de Albuquerque, André L P, Melo, Camila M, Lorenzi-Filho, Geraldo, Genta, Pedro R
Format: Article
Language:English
Subjects:
Aged
Airway management
Chronic obstructive pulmonary disease
Clinical trials
Continuous positive airway pressure
Continuous Positive Airway Pressure - adverse effects
Cross-Over Studies
Female
Humans
Hydrodynamics
Male
Middle Aged
Sleep
Sleep apnea
Sleep Apnea, Obstructive - physiopathology
Sleep Apnea, Obstructive - therapy
Weight Gain - physiology
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Summary:Recent studies have shown that the treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) is associated with weight gain over periods ranging from 3 to 6 months (1-4). However, the mechanisms are conflicting and include reduction in basal metabolic rate (KMR) because of the resolution of OSA and increase in caloric intake leading to increase in fat (4) and lean body mass. Fluid accumulation is a well-known effect of positive pressure ventilation.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.202005-1853LE