Association of dietary acid load with serum bicarbonate in chronic kidney disease (CKD) patients

Background/objectives Diet can affect the acid–base status depending on the balance between the intake of acid-inducing foods and base-inducing foods. The purpose of this study was to estimate the dietary acid load and evaluate its association with serum bicarbonate in patients with stages 3 and 4 c...

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Bibliographic Details
Published in:European journal of clinical nutrition 2020-08, Vol.74 (Suppl 1), p.69-75
Main Authors: Angeloco, Larissa Rodrigues Neto, Arces de Souza, Gabriela Cristina, Romão, Elen Almeida, Frassetto, Lynda, Chiarello, Paula Garcia
Format: Article
Language:English
Subjects:
Acids
Amino acids
Analysis
Animal protein
Bicarbonates
Blood pressure
Body mass index
Body size
Carbonates
Chronic kidney failure
Clinical Nutrition
Creatinine
Diabetes mellitus
Epidemiology
Food
Food intake
Food sources
Internal Medicine
Kidney diseases
Kidneys
Medicine
Medicine & Public Health
Metabolic Diseases
Proteins
Public Health
Quartiles
Regression analysis
Regression models
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Summary:Background/objectives Diet can affect the acid–base status depending on the balance between the intake of acid-inducing foods and base-inducing foods. The purpose of this study was to estimate the dietary acid load and evaluate its association with serum bicarbonate in patients with stages 3 and 4 chronic kidney disease. Subjects/methods One hundred adults (aged ≥ 20 years) with chronic kidney disease (CKD) stages 3 and 4 were enrolled in a cross-sectional study. A food diary was used to estimate the animal and plant protein intakes, which were used in the potential renal acid load (PRAL) formula described by Remer and Manz. PRAL was divided into quartiles. Regression models unadjusted and adjusted for age, gender, body mass index, diabetes, systolic and diastolic blood pressure, creatinine clearance were performed using the stepwise regression method. Results The median level (25th, 75th percentiles) of PRAL was 8.3 mEq/day (1.6, 15.6). The highest quartile of PRAL had a higher consumption of animal protein (77.8 ± 10.9%) and a reduced consumption of plant protein (22.2 ± 10.9%), compared to the lowest quartile (59.5 ± 18.6% animal protein, 40.5 ± 18.6% plant protein), p for trend
ISSN:0954-3007
1476-5640
DOI:10.1038/s41430-020-0689-1