Juxtaglomerular cell tumor: Clinicopathologic evaluation in a large series emphasizing its broad histologic spectrum

The juxtaglomerular cell tumor (JCT) is a rare renal tumor. We re‐evaluated the clinicopathologic features of 21 JCTs to summarize their variable morphologies. Immunohistochemical, fluorescent in situ hybridization and periodic acid–Schiff stains were routinely performed, and four JCT cases were det...

Full description

Saved in:
Bibliographic Details
Published in:Pathology international 2020-11, Vol.70 (11), p.844-856
Main Authors: Zhou, Jun, Zheng, Saifang, Zhang, Yanping, Yu, Yijian, Zhou, Luting, Zhang, Wenjing, Wang, Chaofu, Shen, Qin, Yang, Xiaoqun
Format: Article
Language:English
Subjects:
CD34 antigen
clinicopathologic
Cytoplasm
diagnosis
Familiarity
Fluorescence
Fluorescence in situ hybridization
Growth patterns
juxtaglomerular cell tumor
Metastases
Mitosis
morphologic
Morphology
Necrosis
prognosis
Renin
Secretory vesicles
Synaptophysin
Transmission electron microscopy
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The juxtaglomerular cell tumor (JCT) is a rare renal tumor. We re‐evaluated the clinicopathologic features of 21 JCTs to summarize their variable morphologies. Immunohistochemical, fluorescent in situ hybridization and periodic acid–Schiff stains were routinely performed, and four JCT cases were detected via transmission electron microscopy. The 21 JCTs involved five males and 16 females, ranging in age from 19 years to 69 years (mean, 36.9 years; median, 34 years). The tumors were composed of large, small, or spindle cells with a round, oval or polygonal shape, arranged in various growth patterns. Both necrosis (1/21) and mitosis (2/21, with 1/50HFP, 8/50HFP) was rarely appreciated. All cases were immunoreactive for renin and CD34 (21/21), and few were positive for α‐SMA (13/21;11/21, focally; 2/21, diffusely,), CD117 (9/21, focally) and synaptophysin (3/21, focally). Ultrastructurally, all four cases exhibited secretory granules in varying sizes in the cytoplasm, two of which exhibited cellular junctions. Almost all cases (20/21) had a favorable prognosis, but one succumbed due to bone and hepatic metastases, which corresponds to malignant JCT. Our study demonstrates that JCTs may have atypical clinical presentations and variable histologic appearances. A familiarity with these features may contribute to a correct diagnosis.
ISSN:1320-5463
1440-1827
DOI:10.1111/pin.13009