Sentinel lymph node detection differs when comparing lymphoscintigraphy to lymphography using water soluble iodinated contrast medium and digital radiography in dogs

Sentinel lymph node (SLN) mapping by various means has become standard of care in certain types of human cancers and is receiving more attention in veterinary oncology. Current SLN mapping techniques can be costly and often require advanced imaging equipment. The objective of this prospective, metho...

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Bibliographic Details
Published in:Veterinary radiology & ultrasound 2020-11, Vol.61 (6), p.659-666
Main Authors: Hlusko, Katelyn C., Cole, Robert, Tillson, David Michael, Boothe, Harry W., Almond, Greg, Coggeshall, Whitney S., Matz, Brad M.
Format: Article
Language:English
Subjects:
Animals
Axilla
Cervical Vertebrae
Contrast Media - administration & dosage
Dogs - anatomy & histology
lymphangiogram
lymphangiography
lymphatic mapping
Lymphography - veterinary
Lymphoscintigraphy - veterinary
Male
Radiographic Image Enhancement
Reference Values
Sentinel Lymph Node - diagnostic imaging
Technetium Tc 99m Sulfur Colloid - administration & dosage
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Summary:Sentinel lymph node (SLN) mapping by various means has become standard of care in certain types of human cancers and is receiving more attention in veterinary oncology. Current SLN mapping techniques can be costly and often require advanced imaging equipment. The objective of this prospective, method comparison study was to compare an SLN mapping protocol of lymphoscintigraphy to lymphography using water soluble iodinated contrast medium (WIC) and digital radiography for identification of an SLN. Lymphoscintigraphy and lymphography were performed on eight healthy purpose‐bred dogs using technetium‐99m sulfur colloid and WIC injected into the subcutaneous tissues in a four‐quadrant technique around a predefined area of skin on the brachium. Images were obtained using a gamma camera and digital radiography at different time points post‐injection. Image sequences were evaluated by one of two American College of Veterinary Radiology board‐certified veterinary radiologists. Data obtained were compared between methods using descriptive statistics. An SLN was identified in all dogs with lymphoscintigraphy and seven of eight dogs with lymphography. Agreement between results of the lymphoscintigraphy and lymphography studies was a complete match in three dogs, a partial match in four dogs, and no match in one dog. The SLN detected differed based on the imaging modality used.
ISSN:1058-8183
1740-8261
DOI:10.1111/vru.12908