The Effects of Acute and Chronic Exercise on Paraoxonase-1 (PON1): A Systematic Review With Meta-Analysis

Purpose: To determine the acute and chronic effects of exercise on Paraoxonase-1 (PON1) concentration and activity. Methods: A literature search was performed using 16 electronic databases. Effect sizes (ES) were computed and two-tailed α values < .05 and non-overlapping 95% confidence intervals...

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Bibliographic Details
Published in:Research quarterly for exercise and sport 2022-01, Vol.93 (1), p.130-143
Main Authors: Taylor, James Kyle, Carpio-Rivera, Elizabeth, Chacón-Araya, Yamileth, Grandjean, Peter W., Moncada-Jiménez, José
Format: Article
Language:English
Subjects:
Acute exercise
arylesterase
chronic exercise
lipids
lipoproteins
PON1
Aryldialkylphosphatase - metabolism
Aryldialkylphosphatase - physiology
Exercise - physiology
Humans
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Summary:Purpose: To determine the acute and chronic effects of exercise on Paraoxonase-1 (PON1) concentration and activity. Methods: A literature search was performed using 16 electronic databases. Effect sizes (ES) were computed and two-tailed α values < .05 and non-overlapping 95% confidence intervals (95%CI) were considered statistically significant. Heterogeneity, inconsistency (I 2 ), and small-study effects using the LFK index were examined. Results: Eighteen studies (n = 377 participants) met the criteria for inclusion. The acute effects of exercise on PON1 concentration were trivial and non-significant (ES = −.03, 95%CI = −.39 to .34, p > .05), heterogeneous (p = .05), moderately inconsistent (I 2  = 48%), with minor asymmetry (LFK index = 1.34). The chronic effects of exercise on PON1 concentration were also trivial and non-significant (ES = −.04, 95%CI = −.53 to.45, p > .05), homogenous (p = .65), displayed low inconsistency (I 2  = 0%), and minor asymmetry (LFK index = −1.14). The acute effects of exercise on PON1 activity were trivial and non-significant (ES = .11, 95%CI = −.02 to.24, p > .05), homogenous (p = .85), showed low inconsistency (I 2  = 0%), and no asymmetry (LFK index = .82). The chronic effects of exercise on PON1 activity were trivial and non-significant (ES = .31, 95%CI = −.03 to.65, p > .05), homogenous (p = .17), moderately inconsistent (I 2  = 36%), with no asymmetry (LFK index = .60). Conclusion: Acute and chronic exercise training, overall, exerted a trivial effect on PON1 concentration and activity.
ISSN:0270-1367
2168-3824
DOI:10.1080/02701367.2020.1812493