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Digging metagenomic data of pangolins revealed SARS‐CoV‐2 related viruses and other significant viruses

Pangolin metagenomic data obtained from public databases were used to assemble partial or complete viral genomes showing genetic relationship to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), Sendai virus, flavivirus, picornavirus, parvovirus, and genomovirus, respectively. Most of th...

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Published in:	Journal of Medical Virology 2021-03, Vol.93 (3), p.1786-1791
Main Authors:	Yang, Shixing, Shan, Tongling, Xiao, Yuqing, Zhang, Heteng, Wang, Xiaochun, Shen, Quan, Wang, Yan, Yao, Yuxin, Liu, Qi, Wang, Hao, Zhang, Wen
Format:	Article
Language:	English
Subjects:	Animals Coronaviridae Coronaviruses COVID-19 - virology Genetic relationship Genome, Viral - genetics Genomes Host Specificity - genetics Metagenome - genetics Metagenomics Metagenomics - methods pangolin Pangolins - virology Parvoviruses Phylogeny Recombination Recombination, Genetic - genetics SARS-CoV-2 - genetics SARS‐CoV‐2‐related virus Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Viral diseases Virology Viruses
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creator	Yang, Shixing Shan, Tongling Xiao, Yuqing Zhang, Heteng Wang, Xiaochun Shen, Quan Wang, Yan Yao, Yuxin Liu, Qi Wang, Hao Zhang, Wen
description	Pangolin metagenomic data obtained from public databases were used to assemble partial or complete viral genomes showing genetic relationship to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), Sendai virus, flavivirus, picornavirus, parvovirus, and genomovirus, respectively. Most of these virus genomes showed genomic recombination signals. Phylogeny based on the SARS‐CoV‐2‐related virus sequences assembled in this study and those recently published indicated that pangolin SARS‐CoV‐2‐related viruses were clustered into two sub‐lineages according to geographic sampling sites. These findings suggest the need for further pangolin samples, from different countries, to be collected and analyzed for coronavirus to elucidate whether pangolins are intermittent hosts for SARS‐CoV‐2.
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subjects	Animals Coronaviridae Coronaviruses COVID-19 - virology Genetic relationship Genome, Viral - genetics Genomes Host Specificity - genetics Metagenome - genetics Metagenomics Metagenomics - methods pangolin Pangolins - virology Parvoviruses Phylogeny Recombination Recombination, Genetic - genetics SARS-CoV-2 - genetics SARS‐CoV‐2‐related virus Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Viral diseases Virology Viruses
title	Digging metagenomic data of pangolins revealed SARS‐CoV‐2 related viruses and other significant viruses
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