Characterization of the cortisol response to traumatic hemorrhage and intra-abdominal contamination models in Cynomologus Macaques

• Published in: Molecular and cellular endocrinology 2020-12, Vol.518, p.111036-111036, Article 111036
• Main Authors: Atwood, Rex E., Golden, Dana M., Kaba, Stephen A., Bradley, Matthew J.
• Format: Article
• Language: English
• Subjects: Cortisol; Hemorrhage; Non-human primate; Peritonitis; Trauma
• ISSN: 0303-7207; 1872-8057
• DOI: 10.1016/j.mce.2020.111036

Trauma, hemorrhage, and peritonitis have widely varying impacts on endocrine response in the injured patient. We sought to examine cortisol response in established non-human primate models of traumatic hemorrhage and intra-abdominal contamination. Cynomologus Macaques were separated into two experimental groups, the polytrauma and hemorrhage model, involving a laparoscopic liver resection with uncontrolled hemorrhage, cecal perforation, and soft tissue excision; and the traumatic hemorrhage model, involving only liver resection and uncontrolled hemorrhage. Cortisol levels were measured pre-operatively, at the time of injury, and at regular intervals until post-operative day 1. Cortisol levels increased 600% from the pre-operative value in the polytrauma and hemorrhage model, with minimal changes (20%) in the hemorrhage only model. Cortisol levels increase dramatically in response to polytrauma and intra-abdominal contamination as compared to hemorrhage only. The lack of response in the hemorrhage only group may be due to relative adrenal insufficiency caused by the shock state or lack of enticing stimuli from fecal peritonitis. •Our group has studied cortisol levels in traumatic models in Non Human Primates.•Cortisol levels increase in response to traumatic hemorrhage and fecal peritonitis.•Hemorrhage has minimal effect on cortisol levels when compared to polytrauma.