Secular trends in rates of hospitalisation for lower extremity amputation and 1 year mortality in people with diabetes in Hong Kong, 2001–2016: a retrospective cohort study

• Published in: Diabetologia 2020-12, Vol.63 (12), p.2689-2698
• Main Authors: Wu, Hongjiang, Yang, Aimin, Lau, Eric S. H., Ma, Ronald C. W., Kong, Alice P. S., Chow, Elaine, So, Wing-Yee, Chan, Juliana C. N., Luk, Andrea O. Y.
• Format: Article
• Language: English
• Subjects: Amputation; Cohort analysis; Diabetes; Diabetes mellitus; Hospitalization; Human Physiology; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Mortality; Regression analysis; Surveillance; Trends
• ISSN: 0012-186X; 1432-0428
• DOI: 10.1007/s00125-020-05278-2

Aims/hypothesis We aimed to describe trends in rates of hospitalisation for lower extremity amputation (LEA) and 1 year mortality rates after LEA in people with diabetes in Hong Kong between 2001 and 2016. Methods The Hong Kong Diabetes Surveillance Database is a territory-wide population-based diabetes cohort ( N  = 770,078) identified from the Hong Kong Hospital Authority electronic medical system. We identified LEA events using ICD-9 procedure codes and 1 year mortality after LEA from linkage to the Hong Kong Death Registry. Joinpoint regression models were used to describe the trends. Results Between 2001 and 2016, 6113 hospitalisations for LEAs in men and 4149 in women were recorded in the Hong Kong Diabetes Surveillance Database. The rates of minor LEAs declined by 48.6% (average annual per cent change [AAPC]: −3.8; 95% CI −5.7, −1.9) in men and by 59.5% (AAPC: −6.3; 95% CI −10.6, −1.8) in women. The rates of major LEAs declined by 77.9% (AAPC: −8.0; 95% CI −9.6, −6.5) in men and by 79.3% (AAPC: −10.4; 95% CI −13.1, −7.6) in women. The cumulative 1 year mortality rates after minor and major LEAs were 18.5% and 41.8% in men, and 21.3% and 42.0% in women, respectively, for the whole period. No change was detected in 1 year mortality rates during the surveillance in both sexes. Conclusions/interpretation Although hospitalisation rates for LEAs have declined overall in people with diabetes, there were no improvements in 1 year mortality rates after LEA. Continuous efforts are needed to further prevent LEAs and improve the survival rate of people undergoing LEAs. Graphical abstract