Human permanent tooth sizes are associated with genes encoding oestrogen receptors

• Published in: Journal of orthodontics 2021-03, Vol.48 (1), p.24-32
• Main Authors: Cunha, Arthur S, Vertuan dos Santos, Luiza, Schaffer Pugsley Baratto, Samantha, Abbasoglu, Zerrin, Gerber, Jennifer Tsi, Paza, Aleysson, Matsumoto, Mírian Aiko Nakane, Scariot, Rafaela, Stuani, Maria Bernadete, Küchler, Erika Calvano
• Format: Article
• Language: English
• Subjects: Cross-Sectional Studies; Estrogen Receptor alpha; Estrogen Receptor beta - genetics; Female; Humans; Male; Mandible; Polymorphism, Single Nucleotide - genetics; Receptors, Estrogen
• ISSN: 1465-3125; 1465-3133
• DOI: 10.1177/1465312520958710

Objective: To evaluate if genetic polymorphisms in the oestrogen receptor 1 (ESR1) and oestrogen receptor 2 (ESR2) genes encoded for oestrogen receptors alpha (ERα) and beta (ERβ) are involved in permanent tooth size. Design: Cross-sectional study. Setting: Orthodontic Clinic at School of Dentistry of Ribeirão Preto, University of São Paulo. Participants: A total of 108 orthodontic patients. Materials and Methods: Pre-treatment orthodontic records were evaluated. Dental casts were used to determine the maximum crown measurements of fully erupted permanent teeth in the mesiodistal dimensions. Second and third molars were not included in the analysis. Genomic DNA samples were used for the genotyping of four genetic polymorphisms: ESR1 (rs9340799 and rs2234693) and ESR2 (rs1256049 and rs4986938). The associations between tooth size and sex were evaluated using t test. The associations between tooth size and genotype were analysed with linear regression and adjusted by sex at an alpha of P⩽0.05. Results: Female patients presented smaller tooth size than male patients. A statistically significant difference was observed in almost all teeth (P