Cobalt-Catalyzed C(sp2)–C(sp3) Suzuki–Miyaura Cross Coupling

A cobalt-catalyzed method for the C­(sp2)–C­(sp3) Suzuki–Miyaura cross coupling of aryl boronic esters and alkyl bromides is described. Cobalt–ligand combinations were assayed with high-throughput experimentation, and cobalt­(II) sources with trans-N,N′-dimethylcyclohexane-1,2-diamine (DMCyDA, L1) p...

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Bibliographic Details
Published in:Organic letters 2021-02, Vol.23 (3), p.625-630
Main Authors: Ludwig, Jacob R, Simmons, Eric M, Wisniewski, Steven R, Chirik, Paul J
Format: Article
Language:English
Subjects:
Bromides - chemistry
Catalysis
catalytic activity
cobalt
Cobalt - chemistry
Diamines - chemistry
Esters
Lewis acids
Lewis bases
Ligands
Molecular Structure
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