Altered brain network function during attention-modulated visual processing in multiple sclerosis

Background: Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function during task performance are scarce. Objective: To investigate connectivity within and betwe...

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Bibliographic Details
Published in:Multiple sclerosis 2021-08, Vol.27 (9), p.1341-1349
Main Authors: Veréb, Dániel, Tóth, Eszter, Bozsik, Bence, Király, András, Szabó, Nikoletta, Kincses, Bálint, Kocsis, Krisztián, Faragó, Péter, László, Vécsei, Bencsik, Krisztina, Klivényi, Péter, Kincses, Zsigmond Tamás
Format: Article
Language:English
Subjects:
Attention task
Brain mapping
Cognitive ability
Executive function
Functional magnetic resonance imaging
Information processing
Intraparietal sulcus
Multiple sclerosis
Neural networks
Neuroimaging
Receptive field
Spatial memory
Visual perception
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Summary:Background: Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function during task performance are scarce. Objective: To investigate connectivity within and between task-related networks in multiple sclerosis during a visual attention task as a function of cognitive performance. Methods: A total of 23 relapsing-remitting multiple sclerosis (RRMS) patients and 29 healthy controls underwent task-functional magnetic resonance imaging (fMRI) scans using a visual attention paradigm on a 3T scanner. Scans were analysed using tensor-independent component analysis (TICA). Functional connectivity was calculated within and between components. We assessed cognitive function with the Brief International Cognitive Assessment for MS (BICAMS) battery. Results: TICA extracted components related to visual processing, attention, executive function and the default-mode network. Subject scores of visual/attention-related and executive components were greater in healthy controls (p 
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458520958360