Subjective oral symptoms are insufficient predictors of a positive oral food challenge

Background Subjective oral symptoms, especially if recurrent, might lead to termination of an oral food challenge (OFC) for fear of a subsequent severe reaction. Methods In a single‐center retrospective cohort study, oral food challenges to milk, egg, peanut, sesame, or tree nuts performed between J...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric allergy and immunology 2021-02, Vol.32 (2), p.342-348
Main Authors: Nachshon, Liat, Zipper, Oren, Levy, Michael B., Goldberg, Michael R., Epstein‐Rigby, Naama, Elizur, Arnon, Santos, Alexandra
Format: Article
Language:English
Subjects:
adverse reactions
Allergies
eliciting dose
Food
Food allergies
food allergy
Milk
mouth itchiness
Nuts
oral food challenge
oral pruritus
Patients
Sesamum
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Subjective oral symptoms, especially if recurrent, might lead to termination of an oral food challenge (OFC) for fear of a subsequent severe reaction. Methods In a single‐center retrospective cohort study, oral food challenges to milk, egg, peanut, sesame, or tree nuts performed between January 2016 and January 2018 in patients aged ≥3 years, at the Institute of Allergy, Immunology and Pediatric Pulmonology in Shamir Medical Center, were analyzed. Subjective oral symptoms during the challenge were documented, and their association with the challenge outcome was examined. Results A total of 323 patients underwent 652 oral food challenges to the investigated foods (milk, 71; egg, 22; peanut, 48; sesame, 24; and tree nuts, 487). Subjective oral symptoms were experienced in 237 (36.3%) of all OFCs performed, and their rate was comparable across most foods tested. The rate of positive challenges was significantly higher when subjective oral symptoms were experienced during the challenge than when they were not (69.6% vs 30.4%, respectively, P 
ISSN:0905-6157
1399-3038
DOI:10.1111/pai.13392