The efficacy of inhaled hypertonic saline for bronchiectasis: a meta-analysis of randomized controlled studies

The efficacy of inhaled hypertonic saline for bronchiectasis remains controversial. We conduct a systematic review and meta-analysis to explore the influence of inhaled hypertonic saline versus 0.9% isotonic saline for the treatment of bronchiectasis. We have searched PubMed, EMbase, Web of science,...

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Bibliographic Details
Published in:The American journal of emergency medicine 2020-12, Vol.38 (12), p.2713-2717
Main Authors: Xie, Bingfeng, Liu, Ping, Wu, Qi, Xiang, Weineng
Format: Article
Language:English
Subjects:
Administration, Inhalation
Bias
Body mass index
Bronchiectasis
Bronchiectasis - drug therapy
Bronchiectasis - physiopathology
Cough
Cystic fibrosis
Cytokines
Emergency medical care
Forced Expiratory Volume
Humans
Hydration
Hypertonic saline
Isotonic saline
Meta-analysis
Mucociliary Clearance - physiology
Osmosis
Osmotic Pressure
Quality of life
Randomized controlled trials
Randomized Controlled Trials as Topic
Saline Solution - therapeutic use
Saline Solution, Hypertonic - therapeutic use
Sensitivity analysis
Sputum
Systematic review
Treatment Outcome
Vital Capacity
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Summary:The efficacy of inhaled hypertonic saline for bronchiectasis remains controversial. We conduct a systematic review and meta-analysis to explore the influence of inhaled hypertonic saline versus 0.9% isotonic saline for the treatment of bronchiectasis. We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials (RCTs) assessing the efficacy of inhaled hypertonic saline versus 0.9% isotonic saline for the treatment of bronchiectasis. This meta-analysis was performed using the random-effect model. Four RCTs were included in the meta-analysis. Overall, compared with control group for bronchiectasis, inhaled hypertonic saline had no obvious influence on forced expiratory volume in 1 s (FEV1, SMD = 0.12; 95% CI = -0.06 to 0.30; P = .18), forced vital capacity (FVC, SMD = 0.10; 95% CI = -0.09 to 0.28; P = .30), sputum expectorated (SMD = -0.03; 95% CI = -2.73 to 2.68; P = .99) or Leicester Cough Questionnaire (LCQ) score (SMD = -0.15; 95% CI = -0.89 to 0.58; P = .68). Inhaled hypertonic saline and 0.9% isotonic saline show similar efficacy for bronchiectasis.
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2020.08.042