Secondary antibody deficiency is associated with development of infection in kidney transplantation: Results of a multicenter study

Background We performed a multicenter study to assess the association between secondary antibody deficiency (immunoglobulin G [IgG] hypogammaglobulinemia combined with low levels of specific antibodies) and development of infection in kidney transplantation. Methods We prospectively analyzed 250 adu...

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Bibliographic Details
Published in:Transplant infectious disease 2021-04, Vol.23 (2), p.e13494-n/a
Main Authors: Sarmiento, Elizabeth, Jimenez, Maricela, Natale, Marisa, Rodriguez‐Ferrero, Marisa, Anaya, Fernando, Lopez‐Hoyos, Marcos, Rodrigo, Emilio, Arias, Manuel, Perello, Manel, Seron, Daniel, Karanovic, Boris, Ezzahouri, Ikram, Mezzano, Sergio, Jaramillo, Maria, Calahorra, Leticia, Alarcon, Alba, Navarro, Joaquin, Muñoz, Patricia, Carbone, Javier
Format: Article
Language:English
Subjects:
Antibodies
Antiinfectives and antibacterials
Bacterial diseases
Bacterial infections
Complement component C3
Complement component C4
Confidence intervals
Cytomegalovirus
Hypogammaglobulinemia
IgG antibody
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
infection
Infections
Kidney transplantation
Kidney transplants
Nephelometry
Polysaccharides
Recurrent infection
risk factors
secondary antibody deficiency
Statistical analysis
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Summary:Background We performed a multicenter study to assess the association between secondary antibody deficiency (immunoglobulin G [IgG] hypogammaglobulinemia combined with low levels of specific antibodies) and development of infection in kidney transplantation. Methods We prospectively analyzed 250 adult kidney recipients at four centers. The assessment points were before transplantation and 7 and 30 days after transplantation. The immune parameters were as follows: IgG, IgA, and IgM and complement factors C3 and C4 tested by nephelometry; specific IgG antibodies to cytomegalovirus (CMV) and IgG and IgG2 antibodies to pneumococcal polysaccharide (anti‐PPS) determined using enzyme‐linked immunosorbent assay. The clinical follow‐up period lasted 6 months. The clinical outcomes were CMV disease and recurrent bacterial infections requiring antimicrobial therapy. Statistics: Multivariate logistic regression. Results At day 7, IgG hypogammaglobulinemia (IgG levels 
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.13494