Switching of C–C and C–N Coupling/Cleavage for Hypersensitive Detection of Cu2+ by a Catalytically Mediated 2‑Aminoimidazolyl-Tailored Six-Membered Rhodamine Probe

A robust six-membered rhodamine spirocyclic probe 1 containing a versatile 2-aminoimidazolyl moiety was elaborately designed and synthesized via an attractive C–C and C–N coupling strategy to improve the performance in the detection of ultralow transition metal ions. Probe 1 allowed the highly hyper...

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Bibliographic Details
Published in:Organic letters 2020-11, Vol.22 (21), p.8234-8239
Main Authors: Yang, Lin-Lin, Tang, A-Ling, Wang, Pei-Yi, Yang, Song
Format: Article
Language:English
Online Access:Get full text
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Summary:A robust six-membered rhodamine spirocyclic probe 1 containing a versatile 2-aminoimidazolyl moiety was elaborately designed and synthesized via an attractive C–C and C–N coupling strategy to improve the performance in the detection of ultralow transition metal ions. Probe 1 allowed the highly hypersensitive detection of Cu2+ with a superior picomolar limit of detection (35 pM) and nanomolar naked-eye performance (80 nM) via the switching of C–C and C–N cleavage by a catalytic hydrolysis mode.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c02814