Intravenous magnesium sulfate vs. morphine sulfate in relieving renal colic: A randomized clinical trial

Renal colic emerging from renal stone is virtually the most severe pain which is experienced. Intravenous infusion of morphine sulfate is known as a usual treatment for the disease. This study was designed to compare the efficacy of magnesium sulfate vs morphine sulfate in renal colic relief as for...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of emergency medicine 2021-08, Vol.46, p.188-192
Main Authors: Zolfaghari Sadrabad, Akram, Azimi Abarghouei, Soheila, Farahmand Rad, Reza, Salimi, Yahya
Format: Article
Language:English
Subjects:
Analgesics
Blood pressure
Clinical trials
Drugs
Emergency medical care
Intravenous administration
Kidney stones
Kidneys
Lithiasis
Magnesium sulfate
Morphine
Nausea
Nephrolithiasis
Nervous system
Pain
Pain management
Patients
Randomized controlled trial
Renal colic
Side effects
Sulfates
Vomiting
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c361t-92ea7f4b39d23926c2926d5da4ecc68d48cea2699a7bbd635a255eb18801d47c3
cites cdi_FETCH-LOGICAL-c361t-92ea7f4b39d23926c2926d5da4ecc68d48cea2699a7bbd635a255eb18801d47c3
container_end_page 192
container_issue
container_start_page 188
container_title The American journal of emergency medicine
container_volume 46
creator Zolfaghari Sadrabad, Akram
Azimi Abarghouei, Soheila
Farahmand Rad, Reza
Salimi, Yahya
description Renal colic emerging from renal stone is virtually the most severe pain which is experienced. Intravenous infusion of morphine sulfate is known as a usual treatment for the disease. This study was designed to compare the efficacy of magnesium sulfate vs morphine sulfate in renal colic relief as for analgesic effect as well as lack of morphine sulfate side effects when using magnesium sulfate. We conducted a double-blind randomized clinical trial in renal colic patients who had referred to the emergency department of Shahid Sadoughi Hospital in Yazd, Iran. A total of 80 eligible patients were selected and randomly assigned into two groups; patients in the case group received 50 mg/kg intravenous magnesium sulfate, and those in the control group 0.1 mg/kg intravenous morphine. The primary outcome was the pain score measured on a numerical rating scale at 0, 10 and 20 minutes after infusion. Data were analyzed using SPSS16. The two groups were similar in terms of demographic features and pain intensity at the time of referral (P 
doi_str_mv 10.1016/j.ajem.2020.07.035
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2452095053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S073567572030629X</els_id><sourcerecordid>2452095053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-92ea7f4b39d23926c2926d5da4ecc68d48cea2699a7bbd635a255eb18801d47c3</originalsourceid><addsrcrecordid>eNp9kE1LxDAURYMoOI7-AVcBN25a89E0rbgR8WNAcKPrkEneOClpOibtgP56M4y4cOEmL-SdG7gHoXNKSkpofdWVuoO-ZISRksiScHGAZlRwVjRU0kM0I5KLopZCHqOTlDpCKK1ENUPrRRij3kIYpoR7_R4guanHafIrPQLephL3Q9ysXYDfRxdwBO9g68J7vgXtsRm8M9f4Fkcd7NC7L7DYeBecycsxOu1P0dFK-wRnP3OO3h7uX--eiueXx8Xd7XNheE3HomWg5apa8tYy3rLasHxYYXUFxtSNrRoDmtVtq-VyaWsuNBMClrRpCLWVNHyOLvf_buLwMUEaVe-SAe91gNxRsUow0goieEYv_qDdMMVcJ1NCiLYm2V2m2J4ycUgpwkptout1_FSUqJ181amdfLWTr4hUWX4O3exDkKtuHUSVjINgwLoIZlR2cP_FvwG5p44l</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2555960171</pqid></control><display><type>article</type><title>Intravenous magnesium sulfate vs. morphine sulfate in relieving renal colic: A randomized clinical trial</title><source>ScienceDirect Journals</source><creator>Zolfaghari Sadrabad, Akram ; Azimi Abarghouei, Soheila ; Farahmand Rad, Reza ; Salimi, Yahya</creator><creatorcontrib>Zolfaghari Sadrabad, Akram ; Azimi Abarghouei, Soheila ; Farahmand Rad, Reza ; Salimi, Yahya</creatorcontrib><description>Renal colic emerging from renal stone is virtually the most severe pain which is experienced. Intravenous infusion of morphine sulfate is known as a usual treatment for the disease. This study was designed to compare the efficacy of magnesium sulfate vs morphine sulfate in renal colic relief as for analgesic effect as well as lack of morphine sulfate side effects when using magnesium sulfate. We conducted a double-blind randomized clinical trial in renal colic patients who had referred to the emergency department of Shahid Sadoughi Hospital in Yazd, Iran. A total of 80 eligible patients were selected and randomly assigned into two groups; patients in the case group received 50 mg/kg intravenous magnesium sulfate, and those in the control group 0.1 mg/kg intravenous morphine. The primary outcome was the pain score measured on a numerical rating scale at 0, 10 and 20 minutes after infusion. Data were analyzed using SPSS16. The two groups were similar in terms of demographic features and pain intensity at the time of referral (P &lt;.0001). Ten minutes after drug administration, the pain mean score in the morphine group leveled at 4.88, and in the magnesium group 5.70, which proved to be greater in the morphine group (P- = 0.06). However, the pain mean score turned out to be 3.65 in the morphine group and 3.20 in the magnesium group thus significantly indifferent (P = .48). In this study, we concluded that administration of intravenous 50 mg/kg magnesium sulfate could be as effective as morphine in reducing renal colic without any further complications.</description><identifier>ISSN: 0735-6757</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2020.07.035</identifier><language>eng</language><publisher>Philadelphia: Elsevier Inc</publisher><subject>Analgesics ; Blood pressure ; Clinical trials ; Drugs ; Emergency medical care ; Intravenous administration ; Kidney stones ; Kidneys ; Lithiasis ; Magnesium sulfate ; Morphine ; Nausea ; Nephrolithiasis ; Nervous system ; Pain ; Pain management ; Patients ; Randomized controlled trial ; Renal colic ; Side effects ; Sulfates ; Vomiting</subject><ispartof>The American journal of emergency medicine, 2021-08, Vol.46, p.188-192</ispartof><rights>2020 Elsevier Inc.</rights><rights>2020. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-92ea7f4b39d23926c2926d5da4ecc68d48cea2699a7bbd635a255eb18801d47c3</citedby><cites>FETCH-LOGICAL-c361t-92ea7f4b39d23926c2926d5da4ecc68d48cea2699a7bbd635a255eb18801d47c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Zolfaghari Sadrabad, Akram</creatorcontrib><creatorcontrib>Azimi Abarghouei, Soheila</creatorcontrib><creatorcontrib>Farahmand Rad, Reza</creatorcontrib><creatorcontrib>Salimi, Yahya</creatorcontrib><title>Intravenous magnesium sulfate vs. morphine sulfate in relieving renal colic: A randomized clinical trial</title><title>The American journal of emergency medicine</title><description>Renal colic emerging from renal stone is virtually the most severe pain which is experienced. Intravenous infusion of morphine sulfate is known as a usual treatment for the disease. This study was designed to compare the efficacy of magnesium sulfate vs morphine sulfate in renal colic relief as for analgesic effect as well as lack of morphine sulfate side effects when using magnesium sulfate. We conducted a double-blind randomized clinical trial in renal colic patients who had referred to the emergency department of Shahid Sadoughi Hospital in Yazd, Iran. A total of 80 eligible patients were selected and randomly assigned into two groups; patients in the case group received 50 mg/kg intravenous magnesium sulfate, and those in the control group 0.1 mg/kg intravenous morphine. The primary outcome was the pain score measured on a numerical rating scale at 0, 10 and 20 minutes after infusion. Data were analyzed using SPSS16. The two groups were similar in terms of demographic features and pain intensity at the time of referral (P &lt;.0001). Ten minutes after drug administration, the pain mean score in the morphine group leveled at 4.88, and in the magnesium group 5.70, which proved to be greater in the morphine group (P- = 0.06). However, the pain mean score turned out to be 3.65 in the morphine group and 3.20 in the magnesium group thus significantly indifferent (P = .48). In this study, we concluded that administration of intravenous 50 mg/kg magnesium sulfate could be as effective as morphine in reducing renal colic without any further complications.</description><subject>Analgesics</subject><subject>Blood pressure</subject><subject>Clinical trials</subject><subject>Drugs</subject><subject>Emergency medical care</subject><subject>Intravenous administration</subject><subject>Kidney stones</subject><subject>Kidneys</subject><subject>Lithiasis</subject><subject>Magnesium sulfate</subject><subject>Morphine</subject><subject>Nausea</subject><subject>Nephrolithiasis</subject><subject>Nervous system</subject><subject>Pain</subject><subject>Pain management</subject><subject>Patients</subject><subject>Randomized controlled trial</subject><subject>Renal colic</subject><subject>Side effects</subject><subject>Sulfates</subject><subject>Vomiting</subject><issn>0735-6757</issn><issn>1532-8171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAURYMoOI7-AVcBN25a89E0rbgR8WNAcKPrkEneOClpOibtgP56M4y4cOEmL-SdG7gHoXNKSkpofdWVuoO-ZISRksiScHGAZlRwVjRU0kM0I5KLopZCHqOTlDpCKK1ENUPrRRij3kIYpoR7_R4guanHafIrPQLephL3Q9ysXYDfRxdwBO9g68J7vgXtsRm8M9f4Fkcd7NC7L7DYeBecycsxOu1P0dFK-wRnP3OO3h7uX--eiueXx8Xd7XNheE3HomWg5apa8tYy3rLasHxYYXUFxtSNrRoDmtVtq-VyaWsuNBMClrRpCLWVNHyOLvf_buLwMUEaVe-SAe91gNxRsUow0goieEYv_qDdMMVcJ1NCiLYm2V2m2J4ycUgpwkptout1_FSUqJ181amdfLWTr4hUWX4O3exDkKtuHUSVjINgwLoIZlR2cP_FvwG5p44l</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Zolfaghari Sadrabad, Akram</creator><creator>Azimi Abarghouei, Soheila</creator><creator>Farahmand Rad, Reza</creator><creator>Salimi, Yahya</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202108</creationdate><title>Intravenous magnesium sulfate vs. morphine sulfate in relieving renal colic: A randomized clinical trial</title><author>Zolfaghari Sadrabad, Akram ; Azimi Abarghouei, Soheila ; Farahmand Rad, Reza ; Salimi, Yahya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-92ea7f4b39d23926c2926d5da4ecc68d48cea2699a7bbd635a255eb18801d47c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analgesics</topic><topic>Blood pressure</topic><topic>Clinical trials</topic><topic>Drugs</topic><topic>Emergency medical care</topic><topic>Intravenous administration</topic><topic>Kidney stones</topic><topic>Kidneys</topic><topic>Lithiasis</topic><topic>Magnesium sulfate</topic><topic>Morphine</topic><topic>Nausea</topic><topic>Nephrolithiasis</topic><topic>Nervous system</topic><topic>Pain</topic><topic>Pain management</topic><topic>Patients</topic><topic>Randomized controlled trial</topic><topic>Renal colic</topic><topic>Side effects</topic><topic>Sulfates</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zolfaghari Sadrabad, Akram</creatorcontrib><creatorcontrib>Azimi Abarghouei, Soheila</creatorcontrib><creatorcontrib>Farahmand Rad, Reza</creatorcontrib><creatorcontrib>Salimi, Yahya</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Immunology Abstracts</collection><collection>Health &amp; Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zolfaghari Sadrabad, Akram</au><au>Azimi Abarghouei, Soheila</au><au>Farahmand Rad, Reza</au><au>Salimi, Yahya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravenous magnesium sulfate vs. morphine sulfate in relieving renal colic: A randomized clinical trial</atitle><jtitle>The American journal of emergency medicine</jtitle><date>2021-08</date><risdate>2021</risdate><volume>46</volume><spage>188</spage><epage>192</epage><pages>188-192</pages><issn>0735-6757</issn><eissn>1532-8171</eissn><abstract>Renal colic emerging from renal stone is virtually the most severe pain which is experienced. Intravenous infusion of morphine sulfate is known as a usual treatment for the disease. This study was designed to compare the efficacy of magnesium sulfate vs morphine sulfate in renal colic relief as for analgesic effect as well as lack of morphine sulfate side effects when using magnesium sulfate. We conducted a double-blind randomized clinical trial in renal colic patients who had referred to the emergency department of Shahid Sadoughi Hospital in Yazd, Iran. A total of 80 eligible patients were selected and randomly assigned into two groups; patients in the case group received 50 mg/kg intravenous magnesium sulfate, and those in the control group 0.1 mg/kg intravenous morphine. The primary outcome was the pain score measured on a numerical rating scale at 0, 10 and 20 minutes after infusion. Data were analyzed using SPSS16. The two groups were similar in terms of demographic features and pain intensity at the time of referral (P &lt;.0001). Ten minutes after drug administration, the pain mean score in the morphine group leveled at 4.88, and in the magnesium group 5.70, which proved to be greater in the morphine group (P- = 0.06). However, the pain mean score turned out to be 3.65 in the morphine group and 3.20 in the magnesium group thus significantly indifferent (P = .48). In this study, we concluded that administration of intravenous 50 mg/kg magnesium sulfate could be as effective as morphine in reducing renal colic without any further complications.</abstract><cop>Philadelphia</cop><pub>Elsevier Inc</pub><doi>10.1016/j.ajem.2020.07.035</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0735-6757
ispartof The American journal of emergency medicine, 2021-08, Vol.46, p.188-192
issn 0735-6757
1532-8171
language eng
recordid cdi_proquest_miscellaneous_2452095053
source ScienceDirect Journals
subjects Analgesics
Blood pressure
Clinical trials
Drugs
Emergency medical care
Intravenous administration
Kidney stones
Kidneys
Lithiasis
Magnesium sulfate
Morphine
Nausea
Nephrolithiasis
Nervous system
Pain
Pain management
Patients
Randomized controlled trial
Renal colic
Side effects
Sulfates
Vomiting
title Intravenous magnesium sulfate vs. morphine sulfate in relieving renal colic: A randomized clinical trial
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A56%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intravenous%20magnesium%20sulfate%20vs.%20morphine%20sulfate%20in%20relieving%20renal%20colic:%20A%20randomized%20clinical%20trial&rft.jtitle=The%20American%20journal%20of%20emergency%20medicine&rft.au=Zolfaghari%20Sadrabad,%20Akram&rft.date=2021-08&rft.volume=46&rft.spage=188&rft.epage=192&rft.pages=188-192&rft.issn=0735-6757&rft.eissn=1532-8171&rft_id=info:doi/10.1016/j.ajem.2020.07.035&rft_dat=%3Cproquest_cross%3E2452095053%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c361t-92ea7f4b39d23926c2926d5da4ecc68d48cea2699a7bbd635a255eb18801d47c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2555960171&rft_id=info:pmid/&rfr_iscdi=true