A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation

Neurons are highly polarized cells with a single axon and multiple dendrites derived from the cell body to form tightly associated pre- and postsynaptic compartments. As the biosynthetic machinery is largely restricted to the somatodendritic domain, the vast majority of presynaptic components are sy...

Full description

Saved in:
Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2021-01, Vol.109 (1), p.27-41
Main Authors: Rizalar, Filiz Sila, Roosen, Dorien A., Haucke, Volker
Format: Article
Language:English
Subjects:
Animals
Biosynthesis
Cell body
Dendrites
Fraud
Humans
Information processing
Nervous system
Neurogenesis - physiology
Neurotransmission
Presynaptic Terminals - metabolism
Presynaptic Terminals - ultrastructure
Protein Transport - physiology
Proteins
Recruitment
Synapses
Synapses - metabolism
Synapses - ultrastructure
Synaptic transmission
Synaptic Transmission - physiology
Synaptic vesicles
Synaptic Vesicles - metabolism
Synaptic Vesicles - ultrastructure
Synaptogenesis
Target recognition
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurons are highly polarized cells with a single axon and multiple dendrites derived from the cell body to form tightly associated pre- and postsynaptic compartments. As the biosynthetic machinery is largely restricted to the somatodendritic domain, the vast majority of presynaptic components are synthesized in the neuronal soma, packaged into synaptic precursor vesicles, and actively transported along the axon to sites of presynaptic biogenesis. In contrast with the significant progress that has been made in understanding synaptic transmission and processing of information at the post-synapse, comparably little is known about the formation and dynamic remodeling of the presynaptic compartment. We review here our current understanding of the mechanisms that govern the biogenesis, transport, and assembly of the key components for presynaptic neurotransmission, discuss how alterations in presynaptic assembly may impact nervous system function or lead to disease, and outline key open questions for future research. Synapse formation is critical for brain function. Rizalar et al. review our current understanding of the mechanisms that govern the biogenesis, transport, and assembly of the key components for presynaptic neurotransmission and outline key open questions for future research.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2020.09.038