Progress in Visible Light‐Induced Difluroalkylation of Olefins

• Published in: Chemical record 2021-01, Vol.21 (1), p.69-86
• Main Authors: Laishram, Ronibala Devi, Chen, Jingchao, Fan, Baomin
• Format: Article
• Language: English
• Subjects: Alkenes; Coordination compounds; difluoroalkylation; free-radical; Lipophilicity; Metal complexes; Organic chemistry; Organic compounds; Photocatalysis; photocatalyst; Reagents; Visible-light induced
• ISSN: 1527-8999; 1528-0691
• DOI: 10.1002/tcr.202000094

The incorporation of difluoromethylated (CF2) moiety into potentially useful parent molecules lead to significant changes in metabolic stability, lipophilicity, and solubility of the molecules. Over the past several years, with the advent of new difluoromethylating reagents, great progress has been made in the development of a protocol for the direct incorporation of the CF2H group into organic molecules. Among them, difluroalkylation induced by visible light has emerged as an efficient strategy over the past few years. In particular, this protocol provides a more sustainable alternative to other traditional radical‐triggered reactions in terms of environment, energy, step‐economy, health, and safety. The present review mainly focuses on the development of the photocatalytic difluoroalkylation to olefinic moiety using transition‐metal complexes, organic dyes as the photocatalyst; and some organic compounds as a medium of photocatalysis. Visible light induced difluro‐alkylation has emerged as an efficient strategy over the past few years. In particular, this protocol provides a more sustainable alternative to other traditional radical‐triggered reactions in terms of environment, health, safety and step‐economy. The present review mainly focuses on the development of visible‐light induced difluoroalkylation to olefinic moiety.