Synthesis of Biaryls via Decarbonylative Nickel-Catalyzed Suzuki–Miyaura Cross-Coupling of Aryl Anhydrides

Transition metal-catalyzed cross-couplings have been widely employed in the synthesis of many important molecules in synthetic chemistry for the construction of diverse C–C bonds. Conventional cross-coupling reactions require active electrophilic coupling partners, such as organohalides or sulfonate...

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Bibliographic Details
Published in:Journal of organic chemistry 2020-11, Vol.85 (21), p.14149-14157
Main Authors: Zhou, Jing-Ya, Liu, Rui-Qing, Wang, Cheng-Yi, Zhu, Yong-Ming
Format: Article
Language:English
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Summary:Transition metal-catalyzed cross-couplings have been widely employed in the synthesis of many important molecules in synthetic chemistry for the construction of diverse C–C bonds. Conventional cross-coupling reactions require active electrophilic coupling partners, such as organohalides or sulfonates, which are not environmentally friendly enough. Herein, we disclose the first nickel-catalyzed Suzuki–Miyaura cross-coupling of aryl anhydrides and arylboronic acids for the synthesis of biaryls in a decarbonylation manner. The reaction tolerates a wide range of electron-withdrawing, electron-neutral, and electron-donating substituents in this process.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.0c02266