Tunable dynamics of B cell selection in gut germinal centres

Germinal centres, the structures in which B cells evolve to produce antibodies with high affinity for various antigens, usually form transiently in lymphoid organs in response to infection or immunization. In lymphoid organs associated with the gut, however, germinal centres are chronically present....

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Bibliographic Details
Published in:	Nature (London) 2020-12, Vol.588 (7837), p.321-326
Main Authors:	Nowosad, Carla R., Mesin, Luka, Castro, Tiago B. R., Wichmann, Christopher, Donaldson, Gregory P., Araki, Tatsuya, Schiepers, Ariën, Lockhart, Ainsley A. K., Bilate, Angelina M., Mucida, Daniel, Victora, Gabriel D.
Format:	Article
Language:	English
Subjects:	13/31 14/69 38/91 631/250/2152/2153/1982 631/250/2152/2496 631/250/2499 82/1 Affinity Amino Acid Sequence Animals Antibodies Antigens B-Lymphocytes - cytology B-Lymphocytes - immunology Bacteria Cell fate Clonal selection Clonal Selection, Antigen-Mediated Clone Cells - cytology Clone Cells - immunology Colonization Consortia Fate maps Female Flow cytometry Gastrointestinal Microbiome - immunology Gene mapping Gene sequencing Germ-Free Life Germfree Germinal Center - cytology Germinal Center - immunology Germinal centers Humanities and Social Sciences Immunization Immunoglobulins Intestines - cytology Intestines - immunology Intestines - microbiology Kinetics Lymphocytes B Male Mice Microbiota Microorganisms Monoclonal antibodies multidisciplinary Mutation Positive selection Science Science (multidisciplinary) Steady state
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