Pretreatment lymphocyte‐to‐monocyte ratios predict AIDS‐related diffuse large B‐cell lymphoma overall survival

The lymphocyte‐to‐monocyte ratio (LMR) and platelet‐to‐lymphocyte ratio (PLR) have been reported to be useful for predicting the prognosis of various malignancies, including diffuse large B‐cell lymphoma (DLBCL). However, little is known about the role of LMR and PLR in the prognosis of DLBCL patien...

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Bibliographic Details
Published in:Journal of medical virology 2021-06, Vol.93 (6), p.3907-3914
Main Authors: Zeng, Jing, Zhang, Xiuqun, Jia, Lin, Wu, Yongfeng, Tian, Yakun, Zhang, Yulin
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Anemia
B-cell lymphoma
CD4 antigen
Cell survival
Chemotherapy
diffuse large B‐cell lymphoma
HIV
Human immunodeficiency virus
Lymphocytes
Lymphocytes T
lymphocyte‐to‐monocyte ratio
Lymphoma
Medical prognosis
Monocytes
Multivariate analysis
platelet‐to‐lymphocyte ratio
Prognosis
Survival
Virology
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Summary:The lymphocyte‐to‐monocyte ratio (LMR) and platelet‐to‐lymphocyte ratio (PLR) have been reported to be useful for predicting the prognosis of various malignancies, including diffuse large B‐cell lymphoma (DLBCL). However, little is known about the role of LMR and PLR in the prognosis of DLBCL patients with human immunodeficiency virus (HIV) infection. We retrospectively evaluated the prognostic value of the LMR and PLR in patients with newly diagnosed AIDS‐related diffuse large B‐cell lymphoma (AR‐DLBCL) who were treated with CHOP‐like chemotherapy at a single institution. In 33 AR‐DLBCL patients, the median follow‐up period was 32 months (range: 7–85 months), with an estimated 2‐year overall survival (OS) rate of 79.9%. The univariate analysis confirmed the LMR ≤ 2.74 (p = .015), PLR ≥ 337.7 (p = .019), and moderate anemia (p = .045) were associated with inferior survival. The independent significant association between low LMR and poor OS in the multivariate analysis was identified (HR: 0.033, 95% CI: 0.001–0.853, p = .040). However, PLR (p = .459) and moderate anemia (p = .102) did not retain an independent significance in the multivariate analysis. Moreover, compared with the high‐LMR group, patients with low‐LMR more frequently had B symptoms (p = .010) and lower CD4+T cell count (p 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.26655