Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion

Iron overload triggers the ferroptosis in the heart following ischemia/reperfusion (I/R) and transferrin receptor 1 (TfR1) charges the cellular iron uptake. Bioinformatics analysis shows that the three molecules of ubiquitin-specific protease 7 (USP7), p53 and TfR1 form a unique pathway of USP7/p53/...

Full description

Saved in:
Bibliographic Details
Published in:Free radical biology & medicine 2021-01, Vol.162, p.339-352
Main Authors: Tang, Li-Jing, Zhou, Yuan-Jing, Xiong, Xiao-Ming, Li, Nian-Sheng, Zhang, Jie-Jie, Luo, Xiu-Ju, Peng, Jun
Format: Article
Language:English
Subjects:
Animals
Ferroptosis
Heart
Ischemia
Ischemia/reperfusion
p53
Rats
Rats, Sprague-Dawley
Receptors, Transferrin
Reperfusion
Transferrin receptor 1
Tumor Suppressor Protein p53 - genetics
Ubiquitin-Specific Peptidase 7 - genetics
Ubiquitin-specific protease 7
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!