A new index based on serum creatinine and cystatin C is useful for assessing sarcopenia in patients with advanced cancer

Sarcopenia is a well-known risk factor for inferior cancer outcomes, but the identification of patients at risk remains challenging. A new sarcopenia index (SI), defined as serum creatinine (Cr) × cystatin C (CysC)-based glomerular filtration rate (eGFRCysC), has been reported to be an objective sur...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2021-02, Vol.82, p.111032-111032, Article 111032
Main Authors: Fu, Xiaofen, Tian, Zhen, Wen, Su, Sun, Huihui, Thapa, Sudip, Xiong, Huihua, Liu, Huiquan, Li, Lu, Yu, Shiying
Format: Article
Language:English
Subjects:
Body mass index
Cancer
Clinical medicine
Computed tomography
Confidence intervals
Creatinine
Cystatin C
Fatigue
Glomerular filtration rate
Inflammation
Kidney diseases
Medical records
Muscle strength
Musculoskeletal system
Risk analysis
Risk factors
Sarcopenia
Skeletal muscle
Skeletal muscle mass
Spine
Spine (lumbar)
Statistical analysis
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Summary:Sarcopenia is a well-known risk factor for inferior cancer outcomes, but the identification of patients at risk remains challenging. A new sarcopenia index (SI), defined as serum creatinine (Cr) × cystatin C (CysC)-based glomerular filtration rate (eGFRCysC), has been reported to be an objective surrogate marker for sarcopenia. The aim of this study was to assess whether the SI is associated with sarcopenia and cancer-related fatigue (CRF) in patients with advanced cancer. This cross-sectional study included 182 patients with different types of cancer (cancer stages III/IV; mean age 55.1 ± 11.1 y). Sarcopenia was defined as the presence of both low muscle mass and low muscle strength. The cross-sectional area of skeletal muscle mass (SMA) at the third lumbar spine was estimated by computed tomography (CT). Low muscle mass was defined as a skeletal muscle index (SMA/height2)
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2020.111032