Expression of transmembrane protein aquaporin-3 in oral epithelial dysplasia and oral squamous cell carcinoma

The objective of this study was to evaluate aquaporin-3 (AQP3) expression in patient samples of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC), thereby assessing the potential of AQP3 as a molecular marker for tumor progression. An in vitro comparative study was done to dete...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2021-02, Vol.131 (2), p.202-208
Main Authors: Lekshmy, M.S., Sivakumar, T.T., Joseph, Anna P., Varun, B.R., Mony, Vinod, Reshmi, A.
Format: Article
Language:English
Subjects:
Aquaporins
Biomarkers, Tumor
Carcinoma, Squamous Cell
Dentistry
Head and Neck Neoplasms
Humans
Mouth Mucosa
Mouth Neoplasms
Squamous Cell Carcinoma of Head and Neck
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Summary:The objective of this study was to evaluate aquaporin-3 (AQP3) expression in patient samples of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC), thereby assessing the potential of AQP3 as a molecular marker for tumor progression. An in vitro comparative study was done to determine the AQP3 expression on 20 surgical biopsy specimens each of OED and OSCC using immunohistochemistry. Twenty specimens of normal oral mucosa were kept as controls. The results were statistically analyzed using one-way analysis of variance and post hoc analysis. The expression of AQP3 was analyzed and further semiquantified using H-scores. The mean H-score showed a statistically significant difference between OSCC, OED, and normal oral mucosa (P < .05). There was a significant increase in the expression of AQP3 in OSCC and OED compared to normal oral mucosa. The highest expression was observed in OSCC (P < .01). The observations of the study indicate that staining intensity of AQP3 increased from dysplastic noninvasive lesion to invasive OSCC, suggesting a possible role of AQP3 as a biomarker for tumor progression.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2020.10.013