Accuracy of preoperative cross-sectional imaging in cervical cancer patients undergoing primary radical surgery

• Published in: Gynecologic oncology 2021-02, Vol.160 (2), p.384-388
• Main Authors: Staley, S. Allison, Tucker, Katherine R., Gehrig, Paola A., Clark, Leslie H.
• Format: Article
• Language: English
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1016/j.ygyno.2020.11.001

We aim to describe the false negative (FN) and false positive (FP) rates of preoperative cross-sectional imaging (PCI) prior to radical surgery for cervical cancer. A retrospective cohort study of patients who underwent radical hysterectomy for early-stage cervical cancer from January 2010 until December 2017 at a single tertiary care center was performed. Patients were included if they underwent preoperative PCI and radical surgery. Patient demographics and clinicopathologic information were recorded from medical record review. Descriptive statistics were used. Overall, 106 patients met inclusion criteria. Eighty-four percent (89/106) of patients had no suspicion for metastatic disease on PCI, while 16% (17/106) had suspicion for metastatic disease. Of the 89 without suspicion for metastatic disease on PCI, 16% (14/89) had a false negative study with metastatic disease identified on final surgical pathology. False negative rates by modality were 16% (11/70) for PET/CT and 6% (2/33) for diagnostic CT. Of the 17 cases with suspicion for metastatic disease on imaging, 53% (9/17) were false positive studies with no metastatic disease identified histologically. False positive rates by modality were 7% (5/70) for PET/CT and 12% (4/33) for diagnostic CT. PCI is a tool to help identify patients who are optimal candidates for radical surgery. In this sample, the false negative rate was 16%, and false positive rate was 53% for PCI among women who underwent primary radical surgery. Further study is needed to explore preoperative testing that may more accurately identify optimal surgical candidates. •The majority of patients (72%) underwent pre-treatment cross-sectional imaging prior to radical surgery•16% of imaging results were false negative results with metastatic disease identified on final surgical pathology•53% of imaging results were false positive results based on final surgical pathology