Alternation of supragingival microbiome in patients with cirrhosis of different Child‐Pugh scores

Objectives The aim of this study was to analyze the differences in the taxonomy and functions of oral microbiome between patients with and without cirrhosis. Materials and methods In this study, V4‐16S rDNA amplicon sequencing was used to compare the difference of supragingival microbiome in 42 pati...

Full description

Saved in:
Bibliographic Details
Published in:Oral diseases 2022-01, Vol.28 (1), p.233-242
Main Authors: Bai, Rushui, Bai, Mingshan, Zhao, Zijia, Chen, Ningxin, Yang, Yan, Tang, Zhangui
Format: Article
Language:English
Subjects:
16S rDNA
Carbohydrate metabolism
Cirrhosis
functional prediction
Genera
Humans
Infectious diseases
Liver Cirrhosis
Microbiomes
Microbiota - genetics
oral microbiota
RNA, Ribosomal, 16S - genetics
rRNA 16S
taxonomical analysis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives The aim of this study was to analyze the differences in the taxonomy and functions of oral microbiome between patients with and without cirrhosis. Materials and methods In this study, V4‐16S rDNA amplicon sequencing was used to compare the difference of supragingival microbiome in 42 patients and 12 healthy individuals. Results Overall, 3,223,529 clean reads were generated, with an average of 59,694 ± 1,548 clean reads per sample. A total of 30 phyla, 78 classes, 116 orders, 167 families, 228 genera, and 114 species were detected in the 54 samples. The differences were detected among groups at each taxonomical level. Functional prediction showed that patients with cirrhosis had a significant higher proportion of the genes associated with carbohydrate transport and metabolism, defense mechanisms, infectious diseases, membrane transport, etc. compared with healthy individuals (p 
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.13743