Thionation of Optically Pure N‑C Axially Chiral Quinazolin-4-one Derivatives with Lawesson’s Reagent

The reaction of various optically pure N–C axially chiral quinazolin-4-one derivatives with Lawesson’s reagent proceeded without a marked decrease in optical purity to give optically active quinazoline-4-thione derivatives (93–99% ee) possessing a high rotational barrier in good yields.

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Bibliographic Details
Published in:Journal of organic chemistry 2021-01, Vol.86 (1), p.709-715
Main Authors: Niijima, Erina, Imai, Tomomi, Suzuki, Hayate, Fujimoto, Yuuki, Kitagawa, Osamu
Format: Article
Language:English
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Summary:The reaction of various optically pure N–C axially chiral quinazolin-4-one derivatives with Lawesson’s reagent proceeded without a marked decrease in optical purity to give optically active quinazoline-4-thione derivatives (93–99% ee) possessing a high rotational barrier in good yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.0c02319