Association of cerebral microbleeds with cerebrospinal fluid Alzheimer‐biomarkers and clinical symptoms in early dementia with Lewy bodies

• Published in: International journal of geriatric psychiatry 2021-06, Vol.36 (6), p.851-857
• Main Authors: Mendes, Aline, Noblet, Vincent, Mondino, Mary, Loureiro de Sousa, Paulo, Manji, Sumayya, Archenault, Anne, Casanovas, Michel, Bousiges, Olivier, Philippi, Nathalie, Baloglu, Seyyid, Rauch, Lucie, Cretin, Benjamin, Demuynck, Catherine, Martin‐Hunyadi, Catherine, Blanc, Frederic
• Format: Article
• Language: English
• Subjects: Alzheimer's disease; Basal ganglia; Biomarkers; Central nervous system diseases; cerebral amyloid angiopathy; cerebral microbleeds; Cerebrospinal fluid; Cognitive ability; CSF biomarkers; Dementia; Dementia disorders; Executive function; Geriatric psychiatry; Information processing; Lewy bodies; Lewy‐bodies dementia; Localization; Magnetic resonance imaging; Movement disorders; Neurodegenerative diseases; Sleep; Sleep disorders; Substantia alba
• ISSN: 0885-6230; 1099-1166
• DOI: 10.1002/gps.5485

Objectives To determine the prevalence, localization and associations of cerebral microbleeds (CMB) in dementia with Lewy bodies (DLB) with its core clinical symptoms and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD). We hypothesize DLB patients with CMB have increased amyloid burden compared to those without CMB, which could also translate into clinical differences. Methods Retrospective cross‐sectional analysis from the AlphaLewyMA study (https://clinicaltrials.gov/ct2/show/NCT01876459). Patients underwent a standardized protocol of brain MRI including 3D T1, 3D FLAIR and T2* sequences, and CSF analysis of AD biomarkers. CMB and white matter hyperintensities (WMHs) were visually assessed in prodromal and mild demented (DLB, N = 91) and AD (AD, N = 67) patients. Results CMB prevalence did not differ among DLB and AD (24.2% vs. 37.3%; p = 0.081). CMB were mainly distributed in lobar topographies in both DLB (74%) and AD (89%). CMB in DLB was not associated with global cognitive performance, executive functioning, speed of information processing, or AD CSF biomarkers. Similarly, there was no difference regarding specific clinical symptoms: fluctuations, psychotic phenomena, sleep behavior disorder and Parkinsonism between DLB patients with and without CMB. AD patients with CMB had increased burden of WMH compared to those without (2.1 ± 0.86 vs. 1.4 ± 0.89; p = 0.005), according to Fazekas scale, whereas no significant difference was observed in DLB patients (1.68 ± 0.95 vs. 1.42 ± 0.91; p = 0.25). Conclusion CMB were equally prevalent with similar topographic distribution in both DLB and AD patients. CMB was not associated with CSF AD biomarkers or core clinical symptoms in DLB.