Immune modulating effects of receptor interacting protein 2 (RIP2) in autoinflammation and immunity

Receptor-interacting protein 2 (RIP2) is a kinase that is involved in downstream signaling of nuclear oligomerization domain (NOD)-like receptors NOD1 and 2 sensing bacterial peptidoglycans. RIP2-deficiency or targeting of RIP2 by pharmaceutical inhibitors partially ameliorates inflammatory diseases...

Full description

Saved in:
Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2021-02, Vol.223, p.108648-108648, Article 108648
Main Authors: Hofmann, Sigrun Ruth, Girschick, Leonie, Stein, Robert, Schulze, Felix
Format: Article
Language:English
Subjects:
Apoptosis-associated speck-like protein containing a CARD (ASC)
Caspase-1
IL-1β
Inflammasome
Interleukin-1 converting enzyme
NLRP3
NOD1
NOD2
RIPK2
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Receptor-interacting protein 2 (RIP2) is a kinase that is involved in downstream signaling of nuclear oligomerization domain (NOD)-like receptors NOD1 and 2 sensing bacterial peptidoglycans. RIP2-deficiency or targeting of RIP2 by pharmaceutical inhibitors partially ameliorates inflammatory diseases by reducing pro-inflammatory signaling in response to peptidoglycans. However, RIP2 is widely expressed and interacts with several other proteins suggesting additional functions outside the NOD-signaling pathway. In this review, we discuss the immunological functions of RIP2 and its possible role in autoinflammation and immunity. •RIP2 plays essential roles in the regulation of innate immune signaling.•inflammatory bowel disease is the most associated pathology with NOD-RIP2 signaling.•XIAP antagonists and RIP2 kinase inhibitors are efficient in targeting the NOD2 signaling pathway.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2020.108648