The effects of photobiomodulation on human dermal fibroblasts in vitro: A systematic review

Photobiomodulation (PBM) is reported to impart a range of clinical benefits, from the healing of chronic wounds to athletic performance enhancement. The increasing prevalence of this therapy conflicts with the lack of understanding concerning specific cellular mechanisms induced by PBM. Herein, we s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 2021-01, Vol.214, p.112100-112100, Article 112100
Main Authors: Tripodi, Nicholas, Corcoran, Daniel, Antonello, Peta, Balic, Nicholas, Caddy, Darcy, Knight, Aidan, Meehan, Casey, Sidiroglou, Fotios, Fraser, Sarah, Kiatos, Dimitrios, Husaric, Maja, Apostolopoulos, Vasso, Feehan, Jack
Format: Article
Language:English
Subjects:
Cellular manufacture
Cellular proliferation
Cellular protein expression
Cellular viability
Fibroblasts
Gene expression
Low level light therapy
Membrane potential
Membrane proteins
Mitochondria
Photobiomodulation
Protein biosynthesis
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Photobiomodulation (PBM) is reported to impart a range of clinical benefits, from the healing of chronic wounds to athletic performance enhancement. The increasing prevalence of this therapy conflicts with the lack of understanding concerning specific cellular mechanisms induced by PBM. Herein, we systematically explore the literature base, specifically related to PBM (within the range 600-1070 nm) and its influence on dermal fibroblasts. The existing research in this field is appraised through five areas: cellular proliferation and viability; cellular migration; ATP production and mitochondrial membrane potential; cellular protein expression and synthesis; and gene expression. This review demonstrates that when fibroblasts are irradiated in vitro within a set range of intensities, they exhibit a multitude of positive effects related to the wound healing process. However, the development of an optimal in vitro framework is paramount to improve the reliability and validity of research in this field. •Photobiomodulation is a low-risk and non-invasive medical therapy for conditions such as chronic wounds.•Despite the numerous in vitro studies completed, there are many inconsistencies between the experimental protocols.•Current literature suggests that in vitro fluences from 0.5-5 J/cm2 promote positive physiological responses in fibroblasts.•The effective translation of in vitro photobiomodulation research would be aided by more consistent experimental protocols.
ISSN:1011-1344
1873-2682
DOI:10.1016/j.jphotobiol.2020.112100