High-sugar feeding and increasing cholesterol levels in infants

Hypercholesterolaemia is an important risk factor for cardiovascular disease. Both total and LDL cholesterol levels are three-fold higher at the end of the first year of life and about four-fold higher in adulthood compared with the neonatal period. In the USA, only 25% of infants are exclusively br...

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Bibliographic Details
Published in:European heart journal 2021-03, Vol.42 (12), p.1132-1135
Main Authors: Zubin Maslov, Petra, Hill, Joseph A, Lüscher, Thomas F, Narula, Jagat
Format: Article
Language:English
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Summary:Hypercholesterolaemia is an important risk factor for cardiovascular disease. Both total and LDL cholesterol levels are three-fold higher at the end of the first year of life and about four-fold higher in adulthood compared with the neonatal period. In the USA, only 25% of infants are exclusively breastfed and simple carbohydrate-rich formulas are preferentially consumed. Spikes in fasting glucose and insulin have been reported in formula-fed infants and are associated with higher levels of proprotein convertase subtilisin/kexin type 9, suggesting a potential link between high simple sugar intake and consequent increase in LDL cholesterol in early childhood.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehaa868