Neural responses to threat and reward and changes in inflammation following a mindfulness intervention

• Published in: Psychoneuroendocrinology 2021-03, Vol.125, p.105114-105114, Article 105114
• Main Authors: Dutcher, Janine M., Boyle, Chloe C., Eisenberger, Naomi I., Cole, Steve W., Bower, Julienne E.
• Format: Article
• Language: English
• Subjects: Amygdala; Breast cancer; Breast Neoplasms - therapy; Female; Humans; Inflammation; Meditation; Mindfulness; Neuroimaging; Reward; Survivors; Threat
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/j.psyneuen.2020.105114

Mindfulness meditation has been shown to reduce distress and increase well-being among individuals with chronic disease, including breast cancer survivors. However, the neural correlates of these changes and their links with inflammatory biology are not yet known. The present study examined whether a mindfulness meditation intervention was associated with changes in neural responses to threat and reward from pre- to post-intervention, and whether those neural changes were associated with changes in markers of inflammation in breast cancer survivors. This was a single-arm trial of a standardized, validated 6-week mindfulness meditation intervention. Participants were 20 women who had been diagnosed and treated for early-stage breast cancer. Participants provided peripheral blood samples and underwent a 90-minute neuroimaging scan before and after the intervention, with a focus on tasks known to elicit activity in threat- and reward-related neural regions. There were significant changes in neural responses to the two tasks of interest from pre to post-intervention (ps