Serum uromodulin levels, MR imaging findings, and their relationship with eGFR-based CKD staging in ADPKD patients

• Published in: International urology and nephrology 2021-07, Vol.53 (7), p.1383-1389
• Main Authors: Cansever, Hale Nur, Sari, Funda, Cevikol, Can, Cetinkaya, Ramazan, Süleymanlar, Gultekin, Ersoy, Fevzi
• Format: Article
• Language: English
• Subjects: End-stage renal disease; Epidermal growth factor receptors; Glomerular filtration rate; Kidney diseases; Magnetic resonance imaging; Medicine; Medicine & Public Health; Nephrology; Nephrology - Original Paper; Polycystic kidney; Renal function; Serum levels; Urology
• ISSN: 0301-1623; 1573-2584
• DOI: 10.1007/s11255-020-02730-5

Purpose Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease that may progress to end-stage renal disease, characterized by increased kidney volume due to cystic formations. In this study, we aimed to investigate the relationship between serum uromodulin levels, total kidney volume and estimated glomerular filtration rate (eGFR) in patients with ADPKD. Methods This study included a total of 54 ADPKD patients and 18 healthy volunteers (control group). Total kidney volumes were calculated through magnetic resonance images using ellipsoid method. Serum uromodulin measurements were measured using an ELISA method. Results Serum uromodulin levels were lower in patients compared with the control group (2.47 ± 0.16 vs 2.6 ± 0.28, p  = 0.021). There was no significant difference in uromodulin values among the patients in chronic kidney disease (CKD) stages 1–2, 3 and 4–5. TKV measurements of CKD stage 4–5 patients were significantly higher than the stage 1–2 patients ( p  = 0.015). A negative correlation was observed between TKV and eGFR ( r  = − 0.433, p  = 0.001). A positive correlation was observed between uromodulin and eGFR ( r  = 0.274, p  = 0.02). When the serum levels of uromodulin and the level of eGFR were evaluated using simple linear regression analysis, R 2 value was found to be 0.075, suggesting that 7.5% change in serum uromodulin values corresponds with the change in eGFR value. Conclusion These findings are consistent with previous studies that reported that serum uromodulin may be a good biomarker for demonstrating renal function in the early stages of CKD, before eGFR levels deteriorate. Serum uromodulin level may be useful in demonstrating renal functions in the follow-up of individuals with ADPKD.