Standardized 25‐Hydroxyvitamin D Measurements in Parkinson's Disease Patients With COVID‐19

In healthy individuals, serum 25(OH)D concentrations range between 50 and 125 nmol/L.2 In the absence of convincing data, a concentration of 30 nmol/L has been considered the threshold for (severe) vitamin D deficiency.3 In addition, previous reports have suggested an association between low serum 2...

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Bibliographic Details
Published in:Movement Disorders 2020-09, Vol.35 (9), p.1497-1497
Main Authors: Speeckaert, Marijn M., Speeckaert, Reinhart, Delanghe, Joris R.
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
COVID-19
Humans
Italy
Movement disorders
Neurodegenerative diseases
Parkinson Disease - complications
Parkinson's disease
SARS-CoV-2
standardization
vitamin D
Vitamin D - analogs & derivatives
Vitamin D Deficiency - complications
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Summary:In healthy individuals, serum 25(OH)D concentrations range between 50 and 125 nmol/L.2 In the absence of convincing data, a concentration of 30 nmol/L has been considered the threshold for (severe) vitamin D deficiency.3 In addition, previous reports have suggested an association between low serum 25(OH)D concentrations and the risk of developing PD. However, only a limited number of studies have used a standardized method to determine serum 25(OH)D concentrations. The accuracy is the percentage of bias of the result from the “true” value, which is the target value provided by the National Institute for Standard and Technology (NIST).3 In 2013, a liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay was proposed by the NIST, which is the reference measurement procedure (RMP) for serum 25(OH)D, accepted by the Joint Committee for Traceability in Laboratory Medicine.4 The LC–MS/MS method has the best performance for measuring serum 25(OH)D concentrations in terms of accuracy, in comparison with routinely used immunoassays, which have greater variability.5 Interferences leading to matrix effects in automated immunoassays cannot be overcome by the standardization process. [...]LC–MS/MS methods can fail to separate metabolites with the same mass of 25(OH)D (eg, 3‐epi‐25[OH]D), leading to an overestimation of the serum 25(OH)D concentration.3 The National Institute of Health Office of Dietary supplements has funded the NIST to produce target values and has also supported the vitamin D Standardization Program (VDSP).
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.28213