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Nutritional Supplements and Skeletal Health
Purpose of Review Nutrition influences skeletal health throughout the lifespan, from the impact of maternal intakes during development, through the development of peak bone mass, to the rate of bone loss during aging. However, there are limited data available on the effects of nutritional supplement...
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Published in: | Current osteoporosis reports 2021-02, Vol.19 (1), p.23-33 |
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container_title | Current osteoporosis reports |
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creator | Tabatabai, Laila S. Sellmeyer, Deborah E. |
description | Purpose of Review
Nutrition influences skeletal health throughout the lifespan, from the impact of maternal intakes during development, through the development of peak bone mass, to the rate of bone loss during aging. However, there are limited data available on the effects of nutritional supplements on bone density, let alone fracture risk. This review will assess the current literature, focusing on human studies, and emphasizing nutrients where bone density or fracture data are available.
Recent Findings
Calcium and vitamin D supplements, in combination, reduce fracture risk, particularly in populations with low intakes. Extensive recent analyses have supported the safety of these interventions at recommended intakes. There is growing evidence that specific isoflavones may improve bone density although fracture data are lacking. Multiple other nutrient supplements may benefit skeletal health, but data are limited.
Summary
The effect size of nutrient interventions are relatively small, requiring large sample sizes for trials with bone outcomes, may be difficult to blind, and the impact of supplementation may depend on baseline intake. However, nutrition is the only intervention that can be implemented life long and on a population wide basis. Further investigation is needed into the potential benefits of nutritional supplements to determine in which settings supplements may add benefit in addition to dietary intakes. |
doi_str_mv | 10.1007/s11914-020-00651-x |
format | article |
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Nutrition influences skeletal health throughout the lifespan, from the impact of maternal intakes during development, through the development of peak bone mass, to the rate of bone loss during aging. However, there are limited data available on the effects of nutritional supplements on bone density, let alone fracture risk. This review will assess the current literature, focusing on human studies, and emphasizing nutrients where bone density or fracture data are available.
Recent Findings
Calcium and vitamin D supplements, in combination, reduce fracture risk, particularly in populations with low intakes. Extensive recent analyses have supported the safety of these interventions at recommended intakes. There is growing evidence that specific isoflavones may improve bone density although fracture data are lacking. Multiple other nutrient supplements may benefit skeletal health, but data are limited.
Summary
The effect size of nutrient interventions are relatively small, requiring large sample sizes for trials with bone outcomes, may be difficult to blind, and the impact of supplementation may depend on baseline intake. However, nutrition is the only intervention that can be implemented life long and on a population wide basis. Further investigation is needed into the potential benefits of nutritional supplements to determine in which settings supplements may add benefit in addition to dietary intakes.</description><identifier>ISSN: 1544-1873</identifier><identifier>EISSN: 1544-2241</identifier><identifier>DOI: 10.1007/s11914-020-00651-x</identifier><identifier>PMID: 33420633</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bone Density - drug effects ; Calcium - therapeutic use ; Dietary Supplements ; Epidemiology ; Fractures, Bone - prevention & control ; Humans ; Medicine ; Medicine & Public Health ; Orthopedics ; Osteoporosis - prevention & control ; Section Editors ; Therapeutics and Medical Management (S Jan De Beur and B Clarke ; Topical Collection on Therapeutics and Medical Management ; Vitamin D - therapeutic use</subject><ispartof>Current osteoporosis reports, 2021-02, Vol.19 (1), p.23-33</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-ac598e79a3ef1f9e3ab41f1ef9b58c5e4274737fae45e79c0d159b83c46251d33</citedby><cites>FETCH-LOGICAL-c347t-ac598e79a3ef1f9e3ab41f1ef9b58c5e4274737fae45e79c0d159b83c46251d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33420633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tabatabai, Laila S.</creatorcontrib><creatorcontrib>Sellmeyer, Deborah E.</creatorcontrib><title>Nutritional Supplements and Skeletal Health</title><title>Current osteoporosis reports</title><addtitle>Curr Osteoporos Rep</addtitle><addtitle>Curr Osteoporos Rep</addtitle><description>Purpose of Review
Nutrition influences skeletal health throughout the lifespan, from the impact of maternal intakes during development, through the development of peak bone mass, to the rate of bone loss during aging. However, there are limited data available on the effects of nutritional supplements on bone density, let alone fracture risk. This review will assess the current literature, focusing on human studies, and emphasizing nutrients where bone density or fracture data are available.
Recent Findings
Calcium and vitamin D supplements, in combination, reduce fracture risk, particularly in populations with low intakes. Extensive recent analyses have supported the safety of these interventions at recommended intakes. There is growing evidence that specific isoflavones may improve bone density although fracture data are lacking. Multiple other nutrient supplements may benefit skeletal health, but data are limited.
Summary
The effect size of nutrient interventions are relatively small, requiring large sample sizes for trials with bone outcomes, may be difficult to blind, and the impact of supplementation may depend on baseline intake. However, nutrition is the only intervention that can be implemented life long and on a population wide basis. Further investigation is needed into the potential benefits of nutritional supplements to determine in which settings supplements may add benefit in addition to dietary intakes.</description><subject>Bone Density - drug effects</subject><subject>Calcium - therapeutic use</subject><subject>Dietary Supplements</subject><subject>Epidemiology</subject><subject>Fractures, Bone - prevention & control</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Orthopedics</subject><subject>Osteoporosis - prevention & control</subject><subject>Section Editors</subject><subject>Therapeutics and Medical Management (S Jan De Beur and B Clarke</subject><subject>Topical Collection on Therapeutics and Medical Management</subject><subject>Vitamin D - therapeutic use</subject><issn>1544-1873</issn><issn>1544-2241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwAyxQl0go4PEjTpaoKhSpgkVhbTnJBFLywnak8vcYUliympHuuXdxCDkHeg2UqhsHkIKIKKMRpbGEaHdApiCFiBgTcLj_IVF8Qk6c21LKGAh-TCacC0Zjzqfk6nHwtvJV15p6vhn6vsYGW-_mpi3mm3es0Ydghab2b6fkqDS1w7P9nZGXu-XzYhWtn-4fFrfrKOdC-cjkMk1QpYZjCWWK3GQCSsAyzWSSSxRMCcVVaVDIgOW0AJlmCc9FzCQUnM_I5bjb2-5jQOd1U7kc69q02A1OM6FiGdOYsYCyEc1t55zFUve2aoz91ED1tyQ9StJBkv6RpHehdLHfH7IGi7_Kr5UA8BFwIWpf0eptN9hgyP03-wX_xnGk</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Tabatabai, Laila S.</creator><creator>Sellmeyer, Deborah E.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210201</creationdate><title>Nutritional Supplements and Skeletal Health</title><author>Tabatabai, Laila S. ; Sellmeyer, Deborah E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-ac598e79a3ef1f9e3ab41f1ef9b58c5e4274737fae45e79c0d159b83c46251d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bone Density - drug effects</topic><topic>Calcium - therapeutic use</topic><topic>Dietary Supplements</topic><topic>Epidemiology</topic><topic>Fractures, Bone - prevention & control</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Orthopedics</topic><topic>Osteoporosis - prevention & control</topic><topic>Section Editors</topic><topic>Therapeutics and Medical Management (S Jan De Beur and B Clarke</topic><topic>Topical Collection on Therapeutics and Medical Management</topic><topic>Vitamin D - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tabatabai, Laila S.</creatorcontrib><creatorcontrib>Sellmeyer, Deborah E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current osteoporosis reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tabatabai, Laila S.</au><au>Sellmeyer, Deborah E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nutritional Supplements and Skeletal Health</atitle><jtitle>Current osteoporosis reports</jtitle><stitle>Curr Osteoporos Rep</stitle><addtitle>Curr Osteoporos Rep</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>19</volume><issue>1</issue><spage>23</spage><epage>33</epage><pages>23-33</pages><issn>1544-1873</issn><eissn>1544-2241</eissn><abstract>Purpose of Review
Nutrition influences skeletal health throughout the lifespan, from the impact of maternal intakes during development, through the development of peak bone mass, to the rate of bone loss during aging. However, there are limited data available on the effects of nutritional supplements on bone density, let alone fracture risk. This review will assess the current literature, focusing on human studies, and emphasizing nutrients where bone density or fracture data are available.
Recent Findings
Calcium and vitamin D supplements, in combination, reduce fracture risk, particularly in populations with low intakes. Extensive recent analyses have supported the safety of these interventions at recommended intakes. There is growing evidence that specific isoflavones may improve bone density although fracture data are lacking. Multiple other nutrient supplements may benefit skeletal health, but data are limited.
Summary
The effect size of nutrient interventions are relatively small, requiring large sample sizes for trials with bone outcomes, may be difficult to blind, and the impact of supplementation may depend on baseline intake. However, nutrition is the only intervention that can be implemented life long and on a population wide basis. Further investigation is needed into the potential benefits of nutritional supplements to determine in which settings supplements may add benefit in addition to dietary intakes.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33420633</pmid><doi>10.1007/s11914-020-00651-x</doi><tpages>11</tpages></addata></record> |
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subjects | Bone Density - drug effects Calcium - therapeutic use Dietary Supplements Epidemiology Fractures, Bone - prevention & control Humans Medicine Medicine & Public Health Orthopedics Osteoporosis - prevention & control Section Editors Therapeutics and Medical Management (S Jan De Beur and B Clarke Topical Collection on Therapeutics and Medical Management Vitamin D - therapeutic use |
title | Nutritional Supplements and Skeletal Health |
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