Immune complexome analysis reveals the presence of immune complexes and identifies disease‐specific immune complex antigens in saliva samples from patients with Sjögren’s syndrome

Summary Sjögren’s syndrome (SS) is a chronic autoimmune disease that mainly damages the salivary and lacrimal glands. Immune complex (IC) formation triggers local inflammation through IC deposition and decreased antigen function. Some ICs can leak from the lesion and into the saliva, but no salivary...

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Bibliographic Details
Published in:Clinical and experimental immunology 2021-05, Vol.204 (2), p.212-220
Main Authors: Yamane, K., Nakamura, H., Hamasaki, M., Minei, Y., Aibara, N., Shimizu, T., Kawakami, A., Nakashima, M., Kuroda, N., Ohyama, K.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigen-Antibody Complex - immunology
Antigen-antibody complexes
Antigens
Autoimmune diseases
Autoimmunity - immunology
Cathepsin G
Elastase
Epstein-Barr virus
Epstein-Barr Virus Infections - immunology
Female
Herpesvirus 4, Human - immunology
Homology
Humans
immune complex antigen
immune complexome analysis
Inflammation
Lacrimal gland and Nasolacrimal duct
Leukocytes (neutrophilic)
Male
Microbiomes
Middle Aged
Mimicry
neutrophil
Neutrophils
Oral infection
Original
Peroxidase
Proline
Proteins
Saliva
Saliva - immunology
Sjogren's syndrome
Sjogren's Syndrome - immunology
Sjögren’s syndrome
Xerostomia
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