Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by the selective vulnerability of specific neuronal populations, the molecular signatures of which are largely unknown. To identify and characterize selectively vulnerable neuronal populations, we used single-nucleus RNA sequencing to profile the caudal ento...

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Published in:	Nature neuroscience 2021-02, Vol.24 (2), p.276-287
Main Authors:	Leng, Kun, Li, Emmy, Eser, Rana, Piergies, Antonia, Sit, Rene, Tan, Michelle, Neff, Norma, Li, Song Hua, Rodriguez, Roberta Diehl, Suemoto, Claudia Kimie, Leite, Renata Elaine Paraizo, Ehrenberg, Alexander J., Pasqualucci, Carlos A., Seeley, William W., Spina, Salvatore, Heinsen, Helmut, Grinberg, Lea T., Kampmann, Martin
Format:	Article
Language:	English
Subjects:	38 38/91 631/1647/2217/2018 631/1647/245/2225 631/1647/514/1949 692/699/375/365/1283 82 82/51 Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Animal Genetics and Genomics Astrocytes Astrocytes - metabolism Astrocytes - pathology Autopsy Behavioral Sciences Biological Techniques Biomarkers Biomedical and Life Sciences Biomedicine Brain Cell populations Cortex (entorhinal) Cortex (frontal) Depletion Development and progression Entorhinal Cortex - metabolism Entorhinal Cortex - pathology Female Frontal gyrus Frontal Lobe - metabolism Frontal Lobe - pathology Gene expression Gene sequencing Health aspects Humans Identification and classification Inclusions Male Middle Aged Neurobiology Neurodegenerative diseases Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Neurons Neurons - metabolism Neurons - pathology Neurosciences Populations Resource Ribonucleic acid Risk factors RNA RNA sequencing Subpopulations Tau protein tau Proteins - metabolism
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