Cognitive deficits and rehabilitation mechanisms in mild traumatic brain injury patients revealed by EEG connectivity markers

• Published in: Clinical neurophysiology 2021-02, Vol.132 (2), p.554-567
• Main Authors: Liu, Sinan, Shi, Chaoqun, Ma, Xuying, Zhao, Bingyang, Chen, Xiping, Tao, Luyang
• Format: Article
• Language: English
• Subjects: Event-related oscillations; Event-related potentials; Functional connectivity; Go/NoGo task; mTBI; Neuropsychological assessment
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2020.11.034

•EEG can distinguish mild traumatic brain injury (mTBI) patients at recovery stage from healthy controls in a Go/NoGo task.•MTBI patients with chronic neuropsychological defects exhibited more serious impairments of intrahemispheric connectivity, whereas interhemispheric centro-parietal and frontal connectivity was enhanced.•Centro-parietal connectivity and frontal connectivity are compensatory mechanisms of lacking executive and inhibitory responses after mTBI. To explore the multiple specific biomarkers and cognitive compensatory mechanisms of mild traumatic brain injury (mTBI) patients at recovery stage. The experiment was performed in two sections. In Section I, using event-related potential, event-related oscillation and spatial phase-synchronization, we explored neural dynamics in 24 volunteered healthy controls (HC) and 38 patients at least 6 months post-mTBI (19 with epidural hematoma, EDH; 19 with subdural hematoma, SDH) during a Go/NoGo task. In Section II, according to the neuropsychological scales, patients were divided into sub-groups to assess these electroencephalography (EEG) indicators in identifying different rehabilitation outcomes of mTBI. In Section I, mean amplitudes of NoGo-P3 and P3d were decreased in mTBI patients relative to HC, and NoGo-theta power in the non-injured hemisphere was decreased in SDH patients only. In Section II, patients with chronic neuropsychological defects exhibited more serious impairments of intra-hemispheric connectivity, whereas inter-hemispheric centro-parietal and frontal connectivity were enhanced in response to lesions. EEG distinguished mTBI patients from healthy controls, and estimated different rehabilitation outcomes of mTBI. The centro-parietal and frontal connectivity are the main compensatory mechanism for the recovery of mTBI patients. EEG measurements and network connectivity can track recovery process and mechanism of mTBI.