Effect of body weight on upper airway findings and treatment outcome in children with obstructive sleep apnea

Surgical interventions for obstructive sleep apnea (OSA) are less effective in obese than in normal-weight children. However, the mechanisms that underpin this relationship are not fully understood. Therefore, this study aimed to explore how body weight influences upper airway collapse and treatment...

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Bibliographic Details
Published in:Sleep medicine 2021-03, Vol.79, p.19-28
Main Authors: Van de Perck, E., Van Hoorenbeeck, K., Verhulst, S., Saldien, V., Vanderveken, O.M., Boudewyns, A.
Format: Article
Language:English
Subjects:
Adenotonsillectomy
Body mass index
Drug-induced sleep endoscopy
Obesity
Pediatric
Surgery
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Summary:Surgical interventions for obstructive sleep apnea (OSA) are less effective in obese than in normal-weight children. However, the mechanisms that underpin this relationship are not fully understood. Therefore, this study aimed to explore how body weight influences upper airway collapse and treatment outcome in children with OSA. We conducted a retrospective analysis of prospectively collected data on polysomnography, drug-induced sleep endoscopy (DISE), and treatment outcome in otherwise healthy children with OSA. Associations between body mass index (BMI) z-score and upper airway collapse during DISE were assessed using logistic regression modelling. Treatment success was defined as obstructive apnea-hypopnea index (oAHI) 
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2020.12.028