Association between root abnormalities and related pathogenic genes in patients with generalized aggressive periodontitis

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban 2020-12, Vol.53 (1), p.16-23
• Main Authors: Liu, J, Wang, X E, Lv, D, Qiao, M, Zhang, L, Meng, H X, Xu, L, Mao, M X
• Format: Article
• Language: Chinese
• Subjects: Adult; Aggressive Periodontitis - genetics; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Polymorphism, Single Nucleotide; Receptors, Calcitriol - genetics; Young Adult
• ISSN: 1671-167X

To explore the association between the abnormal root morphology and bone metabolism or root development related gene polymorphism in patients with generalized aggressive periodontitis. In the study, 179 patients with generalized aggressive periodontitis were enrolled, with an average age of (27.23±5.19) years, male / female = 67/112. The average number of teeth remaining in the mouth was (26.80±1.84). Thirteen single nucleotide polymorphisms (SNPs) of nine genes which related to bone metabolism and root development were detected by matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). Root abnormalities were identified using periapical radiographs. The abnormal root morphology included cone-rooted teeth, slender-root teeth, short-rooted teeth, curved-rooted teeth, syncretic-rooted molars, and molar root abnormalities. The number of teeth and incidence of abnormal root morphology in different genotypes of 13 SNPs were analyzed. The constituent ratio of root with root abno