Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1/PGC-1α pathway

Mitochondrial injury plays an essential role in the pathogenesis of diabetic cardiomyopathy (DCM). Previous studies demonstrated that rosmarinic acid (RA) treatment prevented high glucose-induced mitochondrial injury in vitro. However, whether RA can ameliorate cardiac function by preventing mitocho...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2021-03, Vol.546, p.29-34
Main Authors: Diao, Jiayu, Zhao, Hongmou, You, Penghua, You, Hongjun, Wu, Haoyu, Shou, Xiling, Cheng, Gong
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Cinnamates - antagonists & inhibitors
Cinnamates - pharmacology
Cinnamates - therapeutic use
Depsides - antagonists & inhibitors
Depsides - pharmacology
Depsides - therapeutic use
Diabetic Cardiomyopathies - drug therapy
Diabetic Cardiomyopathies - physiopathology
Diabetic cardiomyopathy
Glucose - pharmacology
Male
Mice
Mitochondria
Mitochondria - drug effects
Mitochondria - pathology
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
Oxidative Stress - drug effects
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism
Protective Agents - pharmacology
Protective Agents - therapeutic use
Rosmarinic Acid
Signal Transduction - drug effects
SIRT1
Sirtuin 1 - antagonists & inhibitors
Sirtuin 1 - metabolism
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Summary:Mitochondrial injury plays an essential role in the pathogenesis of diabetic cardiomyopathy (DCM). Previous studies demonstrated that rosmarinic acid (RA) treatment prevented high glucose-induced mitochondrial injury in vitro. However, whether RA can ameliorate cardiac function by preventing mitochondrial injury in DCM is unknown. The SIRT1/PGC-1α pathway has emerged as an important regulator of metabolic control and other mitochondrial functions. The present study was undertaken to determine the effects of RA on mitochondrial and cardiac function in DCM as well as the involvement of the SIRT1/PGC-1α pathway. Our results revealed that RA improved cardiac systolic and diastolic function and prevented mitochondrial injury in DCM, as shown by the reduced blood glucose and lipid levels, increased mitochondrial membrane potential levels, improved adenosine triphosphate synthesis, and inhibited apoptosis (P 
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2021.01.086