Clinical Frailty Score Predicts Long-Term Mortality and Hospitalization Due to Heart Failure After Implantation of Cardiac Implantable Electric Device

• Published in: Circulation Journal 2021/07/21, Vol.85(8), pp.1341-1348
• Main Authors: Matsuda, Yasuhiro, Masuda, Masaharu, Asai, Mitsutoshi, Iida, Osamu, Okamoto, Shin, Ishihara, Takayuki, Nanto, Kiyonori, Kanda, Takashi, Tsujimura, Takuya, Hata, Yosuke, Uematsu, Hiroyuki, Mano, Toshiaki
• Format: Article
• Language: English
• Subjects: Activities of Daily Living; Aged; Cardiac electric implantable device; Clinical Frailty Score; Defibrillators, Implantable; Frailty; Heart failure; Heart Failure - therapy; Hospitalization; Humans; Male; Prognosis; Retrospective Studies; Risk Factors; Treatment Outcome
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-20-0823

Background:Although patients with poor ability to perform activities of daily living, such as those with high Clinical Frailty Score (CFS), will often receive a cardiac implantable electric device (CIED), the indications for implantation in these patients have not been clearly defined. We investigated the association between CFS and prognosis in patients with a CIED.Methods and Results:We retrospectively enrolled 323 consecutive patients who underwent initial device implantation (age, 77 (70–83) years; male, 181 [56%] patients; high-voltage device, 49 [15%] patients), and the CFS was retrospectively estimated. Primary outcome was all-cause death, and the secondary outcome was hospitalization due to heart failure (HF). Median CFS was 4 (3–5) points. During 2 years’ follow-up, all-cause death occurred in 32 patients (10%). Freedom from all-cause death was significantly lower in patients with a high CFS than in those with a low score (1–2 points: 100%, 3–4 points: 92.9%, 5–9 points: 77.3%, P