Characterization of Esophageal and Sphincter Reflexes across Maturation in Dysphagic Infants with Oral Feeding Success vs Infants requiring Gastrostomy

To test the hypothesis that esophageal and sphincteric sensory-motor reflexes are distinct across maturation in infants with dysphagia receiving gastrostomy-tube (G-tube). This is a retrospective review of 29 dysphagic infants ( N  = 15 study requiring gastrostomy, N  = 14 age matched control achiev...

Full description

Saved in:
Bibliographic Details
Published in:Dysphagia 2022-02, Vol.37 (1), p.148-157
Main Authors: Swiader, Nancy, Hasenstab, Kathryn A., Yildiz, Vedat O., Jadcherla, Sudarshan R.
Format: Article
Language:English
Subjects:
Analysis
Child, Preschool
Contractility
Deglutition - physiology
Deglutition disorders
Dysphagia
Esophageal sphincter
Esophageal Sphincter, Upper - physiology
Esophagus
Fruit juices
Gastroenterology
Gastrostomy
Hepatology
Humans
Imaging
Infant
Infants
Manometry
Medicine
Medicine & Public Health
Neonatology
Original Article
Ostomy
Otorhinolaryngology
Peristalsis
Peristalsis - physiology
Pharynx
Pressure
Radiology
Reflex - physiology
Reflexes
Sensory neurons
Sphincter
Therapeutic targets
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To test the hypothesis that esophageal and sphincteric sensory-motor reflexes are distinct across maturation in infants with dysphagia receiving gastrostomy-tube (G-tube). This is a retrospective review of 29 dysphagic infants ( N  = 15 study requiring gastrostomy, N  = 14 age matched control achieving oral feeds) that underwent longitudinal pharyngeal-esophageal manometry at 42.3 (37–50.2) weeks postmenstrual age (PMA) and 48.9 (43.3–57.9) weeks PMA. Graded stimuli (0.1–5 mL) of varying media (air, water, and apple juice) tested esophageal peristaltic reflex, upper esophageal sphincter contractile reflex (UESCR), and lower esophageal sphincter relaxation reflex (LESRR). Comparisons were performed between study and controls and across maturation (time-1 vs time-2). Data represented as mean ± SE or OR (95% CI). Across maturation (time-1 vs time-2): Study infants did not exhibit significant differences across in peristaltic, UES, or LES reflexes (all p  > 0.05). In contrast, controls exhibited increased UES resting pressure (13 ± 3 vs 17 ± 3 mmHg, p  = 0.001), LES resting pressure (22 ± 3 vs 25 ± 3 mmHg, p  
ISSN:0179-051X
1432-0460
DOI:10.1007/s00455-021-10258-8