Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism

Respiratory syncytial virus (RSV) is most commonly associated with upper respiratory tract infections during childhood. The lipid composition of cells and lipogenic enzymes play an important role in RSV infection. There are controversial data about whether lipid biosynthesis regulators such as AMP-a...

Full description

Saved in:
Bibliographic Details
Published in:Archives of virology 2021-04, Vol.166 (4), p.1177-1182
Main Authors: González-García, Luis Didier, Martínez-Castillo, Macario, Vargas-Pavía, Tania Allin, Ulloa-Aguilar, José Manuel, Arévalo-Romero, Haruki, Léon-Reyes, Guadalupe, Helguera-Repetto, Addy Cecilia, García-Cordero, Julio, León-Juárez, Moisés
Format: Article
Language:English
Subjects:
AMP
AMP-activated protein kinase
AMP-Activated Protein Kinases - antagonists & inhibitors
AMP-Activated Protein Kinases - metabolism
Biomedical and Life Sciences
Biomedicine
Brief Report
Cell Line, Tumor
Children
Humans
Infections
Infectious Diseases
Kinases
Lipid composition
Lipid Metabolism
Lipids
Medical Microbiology
Phosphates
Proto-Oncogene Proteins c-akt - metabolism
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - metabolism
Respiratory Syncytial Virus, Human - physiology
Respiratory tract diseases
Virology
Virus Replication
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Respiratory syncytial virus (RSV) is most commonly associated with upper respiratory tract infections during childhood. The lipid composition of cells and lipogenic enzymes play an important role in RSV infection. There are controversial data about whether lipid biosynthesis regulators such as AMP-activated protein kinase (AMPK) are deregulated by RSV. Hence, we examined whether the activation state of AMPK is altered in RSV-infected HEp-2 cells. Our data show that RSV infection inhibits AMPK activity, favoring the activation of downstream lipogenic effectors and cellular lipid anabolism in HEp-2 cells.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-021-04974-7