Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study

Background Inactivation of TP53 , a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs. Methods From May 2003...

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Bibliographic Details
Published in:Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2021-07, Vol.24 (4), p.844-857
Main Authors: Kim, Ki Wook, Kim, Nayoung, Choi, Yonghoon, Kim, Won Seok, Yoon, Hyuk, Shin, Cheol Min, Park, Young Soo, Lee, Dong Ho, Park, Young Suk, Ahn, Sang-Hoon, Park, Do Joong, Kim, Hyung-Ho, Lee, Hye Seung, Kim, Ji-Won, Kim, Jin Won, Lee, Keun-Wook, Chang, Won, Park, Ji Hoon, Lee, Yoon Jin, Lee, Kyoung Ho, Kim, Young Hoon
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Aged
Aged, 80 and over
Cancer Research
Female
Gastrectomy - mortality
Gastric cancer
Gastroenterology
Gene Expression - genetics
Humans
Intestine
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging - classification
Oncology
Original Article
p53 Protein
Prognosis
Retrospective Studies
Stomach Neoplasms - classification
Stomach Neoplasms - genetics
Stomach Neoplasms - mortality
Surgical Oncology
Survival
Survival Rate
Tumor suppressor genes
Tumor Suppressor Protein p53 - metabolism
Young Adult
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Summary:Background Inactivation of TP53 , a tumor suppressor gene, is associated with the development of several malignancies, including gastric cancer (GC). The present study aimed to evaluate the correlation between the overexpression of p53 and survival in different Lauren-type GCs. Methods From May 2003 to December 2019, 3608 GC patients treated endoscopically or surgically at the Seoul National University Bundang Hospital were enrolled for the study. Immunohistochemical staining for p53 was performed on all endoscopic and surgical gastric specimens. Clinicopathologic characteristics with Lauren classification, survival rate, and cancer recurrence were analyzed according to p53 overexpression. Results Among 3608 GC patients, p53 overexpression was seen in 1334 patients (37%). p53 overexpression was associated with lower depth of invasion ( P  = 0.026) and Early gastric cancer ( P  = 0.044) in intestinal-type GC, and with advanced TNM stage ( P  
ISSN:1436-3291
1436-3305
DOI:10.1007/s10120-021-01163-y