Bicuspid-Associated Aortic Root Aneurysm: Mid to Long-Term Outcomes of David V Versus the Bio-Bentall Procedure

• Published in: Seminars in thoracic and cardiovascular surgery 2021-01, Vol.33 (4), p.933-943
• Main Authors: Nguyen, Stephanie N., MD, Yamabe, Tsuyoshi, MD, Zhao, Yanling, MS, Kurlansky, Paul A., MD, George, Isaac, MD, Smith, Craig R., MD, Takayama, Hiroo, MD, PhD
• Format: Article
• Language: English
• Subjects: Aortic Aneurysm, Thoracic - diagnostic imaging; Aortic Aneurysm, Thoracic - etiology; Aortic Aneurysm, Thoracic - surgery; Aortic root aneurysm; Aortic Valve - diagnostic imaging; Aortic Valve - surgery; Aortic Valve Insufficiency - diagnostic imaging; Aortic Valve Insufficiency - etiology; Aortic Valve Insufficiency - surgery; Aortic valve repair; Bicuspid aortic valve; Biological Bentall; Blood Vessel Prosthesis Implantation; Cardiothoracic Surgery; Heart Valve Prosthesis Implantation; Humans; Retrospective Studies; Treatment Outcome; Valve-sparing root replacement
• ISSN: 1043-0679; 1532-9488
• DOI: 10.1053/j.semtcvs.2021.02.004

David V valve-sparing root replacement (VSRR) and bio-Bentall (BB) are increasingly performed for aortic root aneurysms associated with a bicuspid aortic valve (BAV). However, durability remains a concern in both procedures. We compared the 10-year outcomes of VSRR vs BB for BAV-associated root aneurysms. A retrospective review identified 134 patients with a BAV-associated root aneurysm who underwent VSRR ( n = 65) or BB ( n = 69) from 2005 to 2019. Patients with aortic stenosis, endocarditis, previous aortic valve replacement, and emergent cases were excluded. Propensity-score matching was performed, resulting in 2 risk-adjusted groups ( n = 40 per group). Median follow-up was 6.21 (1.43–8.28) years. The VSRR cohort was younger (46.0 years vs 56.0 years, P < 0.001) and had a lower incidence of at least moderate aortic insufficiency (AI) (78.5% vs 92.8%, P = 0.02). The incidence of Marfan syndrome, aortic root diameter, and ascending aortic diameter were similar. In-hospital mortality was 1.5% ( n = 1) and 1.4% ( n = 1) for VSRR and BB, respectively. There was no difference between VSRR and BB in 10-year survival (98.3% [95% confidence interval (CI): 88.6–99.8%] vs 96.2% [95% CI: 85.5–99.0%], P = 0.567) and aortic valve reintervention at 10 years (16.1% [95% CI: 6.3–29.8%] vs 12.9% [95% CI: 3.7–28.0%], P = 0.309). The most common reason for valve reintervention in both groups was AI. Survival and valve reintervention at 10 years were similar in the matched cohort. David V VSRR yields similar mid to long-term outcomes to BB for select patients with a BAV-associated aortic root aneurysm in regards to survival and reintervention rates. Further studies comparing longer term outcomes between root replacement techniques and native valve durability are needed.