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Role of adipokines in the ovarian function: Oogenesis and steroidogenesis
•Adipose tissue-derived adipokines can be involved in ovarian functions.•Some studies have suggested the role of adipokines in follicular development and oogenesis and ovarian steroidogenesis.•Abnormal levels of adipokines could be associated with ovarian-related disorders.•More standardized studies...
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Published in: | The Journal of steroid biochemistry and molecular biology 2021-05, Vol.209, p.105852-105852, Article 105852 |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Adipose tissue-derived adipokines can be involved in ovarian functions.•Some studies have suggested the role of adipokines in follicular development and oogenesis and ovarian steroidogenesis.•Abnormal levels of adipokines could be associated with ovarian-related disorders.•More standardized studies may reveal the association of adipokines and ART outcomes in future.
Adipokines are mainly produced by adipose tissue; however, their expression has been reported in other organs including female reproductive tissues. Therefore, adipokines have opened new avenues of research in female fertility. In this regard, studies reported different roles for certain adipokines in ovarian function, although the role of other recently identified adipokines is still controversial. It seems that adipokines are essential for normal ovarian function and their abnormal levels could be associated with ovarian-related disorders. The objective of this study is to review the available information regarding the role of adipokines in ovarian functions including follicular development, oogenesis and steroidogenesis and also their involvement in ovary-related disorders. |
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ISSN: | 0960-0760 1879-1220 |
DOI: | 10.1016/j.jsbmb.2021.105852 |