A PRISMA-compliant meta-analysis on association between X-ray repair cross complementing (XRCC1, XRCC2, and XRCC3) polymorphisms and oral cancer susceptibility

• Published in: Gene 2021-05, Vol.781, p.145524-145524, Article 145524
• Main Authors: Mozaffari, Hamid Reza, Rostamnia, Maryam, Sharifi, Roohollah, Safaei, Mohsen, Zavattaro, Elisa, Tadakamadla, Santosh Kumar, Imani, Mohammad Moslem, Sadeghi, Masoud, Golshah, Amin, Moradpoor, Hedaiat, Rezaei, Farzad, Omidpanah, Neda, Hatami, Masoud
• Format: Article
• Language: English
• Subjects: DNA Repair; DNA-Binding Proteins - genetics; Genetic Predisposition to Disease; Humans; Mouth Neoplasms - genetics; Oral carcinoma; Oral squamous cell carcinoma; Polymorphism; Polymorphism, Genetic; X-ray repair cross complementing; X-ray Repair Cross Complementing Protein 1 - genetics
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2021.145524

•There was an association between XRCC1 rs1799782 polymorphism and OC risk.•There was an association between XRCC2 rs2040639 polymorphism and OC risk.•T allele and CT genotype of rs1799782 polymorphism had an elevated risk for OC.•G allele and GG genotype of rs2040639 polymorphism had a protective role for OC. Oral Cancer (OC) is one of the leading causes of death and the disease mainly occurs over 50 years of age. Herein, a meta-analysis aimed to assess the association between X-ray repair cross complementing (XRCC) polymorphisms and OC risk. Four databases were searched extensively until June 5, 2020. Subgroup analysis, meta-regression, and funnel plots, as well as the quality assessment were estimated. Fifteen studies were entered to the analysis. With regards to allele, homozygote, heterozygote, recessive, and dominant models, the pooled ORs for XRCC1 rs1799782 polymorphism were 1.51 (P = 0.01), 1.45 (P = 0.11), 1.45 (P = 0.0003), 1.44 (P = 0.0002), and 1.29 (P = 0.26); for XRCC1 rs1799782 polymorphism were 1.65 (P = 0.11), 1.50 (P = 0.33), 1.06 (P = 0.83), 1.57 (P = 0.12), and 1.32 (P = 0.45); for XRCC1 rs25489 polymorphism were 0.01 (P = 0.19), 1.44 (P = 0.48), 1.21 (P = 0.72), 1.17 (P = 0.19), and 1.38 (P = 0.54); for XRCC2 rs2040639 polymorphism were 0.68 (P = 0.0002), 0.63 (P = 0.02), 0.95 (P = 0.92), 0.79 (P = 0.49), and 0.61 (P = 0.005); and for XRCC3 rs861539 polymorphism were 1.24 (P = 0.20), 1.28 (P = 0.48), 0.99 (P = 0.95), 1.15 (P = 0.46), and 1.52 (P = 0.15), respectively. The T allele and CT genotype of XRCC1 rs1799782 polymorphism had an elevated risk, whereas the G allele and GG genotype of XRCC2 rs2040639 polymorphism had a protective role in OC.